Another factor heightening interest in semi-solid dosage forms is the quantity of new active pharmaceutical ingredients (API) lacking aqueous solubility
This technology can enable successful clinical translation of promising chemotherapeutics whose success would otherwise be prevented due to poor aqueous solubility
and reliance on toxic excipients.
This edition contains new tables and updates, especially in the following areas: fluid properties, biochemistry, analytical chemistry, astronomy, and geophysics, with new material on topics such as aqueous solubility
of organic compounds, satellites of the planets, and properties of refrigerants.
The aqueous solubility
of paclitaxel was increased by several orders of magnitude in the presence of DENA.
values for 24 samples compared favorably with results obtained by other methods
The membrane is suitable for applications including natural product screening, aqueous solubility
testing and total drug analysis.
The partitioning of each of the individual chemicals between the water and the sediment compartments is governed by many factors, including aqueous solubility
, sediment binding, pH, and temperature.
Low-polarity organic contaminants, such as polychlorinated biphenyls (PCBs) and polyaromatic hydrocarbons (PAHs), are very persistent in the environment due to their low aqueous solubility
and poor bioavailability.
2), their aqueous solubility
was lower than that of isobutyryl thiocholine as shown in Table 2.
Buss said his firm suspects the deeper TCE represents a dense nonaqueous phase liquid (DNAPL) because "concentrations found in wells had values that were greater than 1% of the aqueous solubility
limit for TCE.
Demand is high for this technology, since more than 40% of drugs in development are estimated to have low aqueous solubility
During this process, compounds that suffer from low aqueous solubility
need to be paired with excipients that can adequately solubilize them.
Taking advantage of the aqueous solubility
of the vitamin, previous work has demonstrated that the vitamin can be estimated in mixtures that are also 0.
Underpinned by pharmaceutical-industry estimates that approximately 40% of lipophilic therapeutic molecules are rejected because of their poor aqueous solubility
and formulation-stability issues, one of the main challenges facing modern pharmaceutical science is the development of carrier vehicles for the extended delivery of such drug candidates.
Comparison of Chromatographic and Spectroscopic Methods Used to Rank Compounds for Aqueous Solubility