Key Words: apoptosis
, critical illness, endotoxaemia, lymphocyte, sepsis
Existen dos patrones principales de muerte celular que son necrosis y apoptosis
La necrosis es un tipo de muerte celular accidental que implica la liberacion del contenido celular de la celula necrotica al tejido con la consiguiente provocacion de inflamacion y dano tisular.
In the present study, we evaluated the in situ expression of the proinflammatory cytokines interleukin 1 (IL-1), interferon [gamma] (IFN-[gamma]), and TNF-[alpha], the proapoptotic inducers Fas and inducible nitric oxide synthase (iNOS), and the apoptosis
inhibitor Bcl-2, as well as the presence of apoptosis
in skin biopsies from patients with EPF.
Inhibition or depletion of the protein also caused preferential apoptosis
in a variety of malignant cells in culture.
is the capacity of a cell to undergo programmed cell death; in response to a stimulus, a pathway is triggered that leads to the destruction of the cell by a characteristic set of reactions that require energy.
The mechanisms by which cells execute apoptosis
, or natural cell death, involve the irreversible activation of key enzymes which effectively complete the highly controlled dismantling of a cell's structure.
Biomarker analysis of blood samples from patients with cancer treated with CYC202 demonstrated that 54% (14 of 26 analyzed) tested positive for cancer cell death or apoptosis
following single agent treatment with the drug.
We observed that the WNV-Cp protein is a pathogenic protein, which drives apoptosis
in vitro through the mitochodrial/caspase-9 pathway.
When their usefulness has ended, most cells succumb to a natural process of programmed cell death called apoptosis
Increasing evidence now suggests that the central dogma of myocardial infarction pathophysiology, cell death from necrosis, should now concomitantly include discussion of apoptosis
, or programed cell death [1-7].
The main application of apoptosis
research is presently in cancer treatment.
is one of the pathological features of Alzheimer's disease (AD).
These nine papers address classic issues in cell apoptosis
from the last few years, including the pro-and anti-apoptotic role of ubiquinone, cytochemical and apoptotic markers of tissue remodeling, chemical messengers as male germ cell apoptosis
in human ejaculated spermatozoa, reactive oxygen species-mediated apoptosis
, photoinduced apaptosis by photosensitizer drugs, apoptosis
during pregnancy and a paper that takes the position that snake-like chromatin is not a form of apoptosis
Dose-dependently elevated mRNA and protein levels of Fas, and promoted apoptotic initiator caspase-8 (active form), a molecule of a death-receptor-dependent pathway, coupled with unaltered or decreased levels of cytosolic cytochrome c and the apoptotic initiator caspase-9 (active form), molecules of mitochondria-dependent pathways, may be indicative of cardiac apoptosis
, which is Fas death-receptor apoptotic-signaling dependent, but not mitochondria pathway dependent in rats exposed to second-hand smoke (SHS).
In neurodegeneration, such as Alzheimer's disease (AD), apoptosis
results in the loss of valuable neurons.