apomorphine


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Related to apomorphine: Apomorphine hydrochloride
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Words related to apomorphine

a morphine derivative that is not as strong as morphine

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Such patients who have early clinical features of PD but a negative response to the levodopa test may be challenged by the apomorphine test to see if they show any response.
has submitted a new drug application (NDA) to the US Food and Drug Administration for apomorphine sublingual film (APL-130277) to treat motor fluctuations (OFF episodes) experienced by people living with Parkinson's disease (PD), the company said.
Pathological rotation is measured in response to the administration of either the dopamine (DA) receptor agonist apomorphine or the DA-releasing drug amphetamine [43,44, 59, 60].
Treatment with melatonin (1 and lOmg/ kg, i.p.) before apomorphine administration.
In patients who develop DDS, dopamine replacement therapy should be prescribed in low doses; drugs such as apomorphine should be avoided, and treatments with long-term effects should be preferred.
Behavioral test began at 2 weeks after operation, using intraperitoneal injection of Apomorphine (0.5mg/kg), when rats were constantly turned to the left and the rotational number > 210 r/30 min is regarded as a successful model of PD.
Stereotypical behavior is a common feature manifested in schizophrenia and is increased by apomorphine probably through D2 receptors.
(14,17) Research focusing on dopaminergic drugs (such as levodopa, pergolide, and apomorphine) has yielded mixed results in women with HSDD.
Levodopa or apomorphine challenge should be considered in patients in whom the diagnosis of PD is in question after clinical evaluation.
These investigators administered two proteasomal inhibitors (epoxomicin and PSI) to rats over a 14-day period and then observed a progressive deterioration in motor function over a 2-week period, which improved after administration of the dopamine agonist apomorphine. Examination of the brains of these animals showed not only nigral cell loss with a corresponding striatal dopamine depletion but also neurodegeneration in the locus coeruleus, dorsal motor nucleus of the vagus, and the nucleus basalis of Meynert, a pattern of cell loss that is strikingly similar to that seen in Parkinson's disease and is not observed in any other of the toxicant-induced animal models of Parkinson's disease.
SAN FRANCISCO -- A single dose of subcutaneous apomorphine rapidly and effectively reverses for at least 90 minutes the hypomobility, or "off," episodes that are common in patients with advanced Parkinson's disease, William C.
SAN FRANCISCO -- A single dose of subcutaneous apomorphine rapidly and effectively reverses for at least 90 minutes the hypomobility, or "off" episodes that are common in patients with advanced Parkinson's disease, Dr.
"Successful Incorporation of the Severe Head Injury Guidelines into a Phased-Outcome Clinical Pathway," written by Laura Mcilvoy, David Spain, George Racque, Todd Vitaz, Phillip Boaz, and Kimberly Meyer [April 2001, 33(2): 72-78] won a trophy award; "Cerebral Oxygenation in the Traumatically Brain-Injured Patient: Are ICP and CPP Enough?" written by Genell Hilton [October 2000, 32(5): 278-282] won a certificate award; and "Apomorphine in the Treatment of Parkinson's Disease," written by Peter Hagell and Per Odin [February 2001, 33(1): 21-34] won honorable mention.
That's similar to the response seen when the researchers gave the same patients a drug, apomorphine, known to briefly raise dopamine concentrations in the brain.
Since oral medications are an attractive treatment option, a number of other oral medications are currently under investigation (see phentolamine and apomorphine below).