While heat can sometimes trigger the apocrine
sweat glands, these glands are usually activated by stress and hormonal changes, which is why they play a significant role in cold sweats.
There are painful, deep seated inflamed lesions in the apocrine
gland-bearing areas of the body; most commonly the axillary, inguinal and anogenital regions.
8) Interestingly, differences in recurrent alterations were also observed between apocrine
pleomorphic LCIS and nonapocrine pleomorphic LCIS, which included a gain of 6p (15%) and losses of 3q (22%), 11q (32%), 13q (25%), and 17p (45%).
It was diagnosed as an apocrine
adenocarcinoma developed on the background of a SESD, suggesting a malignant potential for this otherwise benign lesion (5)
which in the diagram contains an apocrine
gland, is shown in Figure 6.
Histopathology of the lesions showed a well-fined tumor composed of glandular formation in the whole dermis; the glands were lined with apocrine
metaplastic epithelium formed by cuboidal cells with basophilic nuclear and eosinophilic cytoplasm.
HS is a chronic, recurrent, inflammatory skin disease, which commonly develops post-puberty in skin regions bearing apocrine
glands, notably axillae, inguinal and anogenital areas.
In addition to these neoplasms, melanomas, adenocarcinomas, histiocytomas, apocrine
gland adenocarcinomas were reported by other authors (Goldshmidt and Hendrick, 2002, Sawale et al.
Histopathology diagnoses were squamous cell carcinoma (three cases), basal cell carcinoma, perianal mucinous adenocarcinoma, hepatoid carcinoma, and apocrine
carcinoma with squamous differentiation.
Sclerosing adenosis is part of the spectrum of fibrocystic changes in the breast, and it is strongly associated with various proliferative lesions, including epithelial hyperplasia, intraductal papilloma, complex sclerosing lesions, and apocrine
Hidradenitis suppurativa is a chronic relapsing inflammatory skin condition affecting the apocrine
Hidradenitis suppurativa is characterized by secondary inflammation of the apocrine
glands, which produces inflamed nodules and abscesses, primarily in the axillae, groin, and anogenital region.
These lesions, once believed to represent a disease of the sweat glands, now are thought to arise in the terminal hair follicles in the apocrine
gland--bearing areas of the body.
The corneoconjunctival mass contained well-developed hair follicles as well as apocrine
and sebaceous glands (Fig.
Cytologic criteria were Nuclear morphology (Large nuclei, Anisonucleosis, Hyperchromatic nuclei, Vesicular nuclei, Chromatin clumping, Prominent nucleoli, Multiple nucleoli), and Cellular morphology (Comet cells, Signet ring cells, Vacuolar cytoplasm, Granular cytoplasm, Apocrine
cells, Ractive ductal cells, Squamous cells).