crisis

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Related to aplastic crisis: aplastic anemia, sequestration crisis
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Synonyms for crisis

Synonyms for crisis

a highly volatile dangerous situation requiring immediate remedial action

Words related to crisis

an unstable situation of extreme danger or difficulty

a crucial stage or turning point in the course of something

References in periodicals archive ?
Aplastic crisis and acute splenic sequestration crisis.
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease.
Knowing HPV B19 as the most common causative agent in the development of aplastic crisis in hemolytic anemias; specifically hereditary spherocytosis polymerase chain reaction (PCR) for HPV B19, DNA was performed which was positive in all three patients (Figures 1 and 2).
These family members were typical examples of the occurrence of aplastic crisis due to HPV B 19 complicating HS simultaneously in a family.
Parvovirus-B19 is the causative agent of various forms of hematologic diseases, among which transient aplastic crisis in patients with underlying hemolytic anemia, chronic hypoplastic anemia-PRC aplasia in immunocompromised patients and hydrops fetalis in pregnant women are the most common.
Although transient aplastic crisis is self-limited, red cell transfusion as a supportive treatment should be provided in case of acute anemia.
Patients with hematologic problems that are associated with a high RBC turnover rate are at risk for developing a transient aplastic crisis when infected with parvovirus B19 (Gillette, 1993).
It is important to note that children with aplastic crisis are highly communicable throughout the crisis (AAP, 1990).
In sickle cell disease and other hereditary and acquired hemolytic anemias, acute B19 infection results in transient aplastic crisis, in which hemoglobin levels fall precipitously, anemia becomes life threatening, and congestive heart failure may ensue.
MedImmune believes a successful B19 parvovirus vaccine could be used both to immunize women entering their child-bearing years to protect them from experiencing B19 parvovirus-induced miscarriages and to vaccinate children with sickle cell anemia to protect them against transient aplastic crisis.