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Immunosuppressive therapy with antithymocyte globulin and cyclosporine for prolonged marrow failure after hemophagocytic syndrome.
Allogenic HSCT was performed in August 2006 after conditioning with total body irradiation (200 cGy, day -8 before HSCT surgery), fludarabine (days -7 to -4), antithymocyte globulin (days -4 to -1), and cyclophosphamide (days -3 to -2).
Use of the immunosuppressant antithymocyte globulin (ATG) increases the risk of cytomegalovirus (CMV) infection and disease during the early post-transplant period among cadaveric kidney recipients, according to Chinese researchers.
Abstract 2773-Low Dose Antithymocyte Globulin Incorporated into graft-versus-host disease (GVHD) Prophylaxis for Matched Related Donor Stem Cell Transplantation Results in Low Morbidity and No Mortality from Acute GVHD.
All Class III patients received conditioning regimen as per Pesaro Protocol 26 and antithymocyte globulin (ATG) except one patient who had received Pesaro Protocol 26 without ATG.
Antithymocyte globulin may also have a role in therapy (60).
With no therapeutic standard for steroid-resistant GVHD yet to be established, various agents are used to treat the condition, including antithymocyte globulin (ATG) and monoclonal anti-bodies.
The conditioning regimen for the transplant consisted of busulfan, cyclophosphamid, and antithymocyte globulin administered with a Hickman catheter.
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Immunosuppression consisted of antithymocyte globulin induction, followed by a regimen of tacrolimus, mycophenolate mofetil, and corticosteroids.