In the 42-site Clinical Antipsychotic Trials of Intervention Effectiveness Alzheimer's disease RCT, 421 outpatients with Alzheimer's disease and BPSD were randomized to an SGA (risperidone, olanzapine, or quetiapine) or placebo.
Patterns of antipsychotic use in older dementia patients
He was lead author of a recent Spanish multidisciplinary consensus report on iatrogenic hyperprolactinemia secondary to antipsychotic
The use of non-pharmacological management is preferred as antipsychotic
medication may elicit interactions with neuroreceptors that may adversely affect residents' health, e.
Methods: Demographics of patients, type of exposure, distribution according to the reason, the amount of the exposed antipsychotics
, clinical findings, the length of hospital stay, and the outcome of the patients in typical and atypical antipsychotic
exposures were analyzed.
Rapid growth of antipsychotics
can be attributed to the rising prevalence of psychosis and other mental disorders.
As a selective serotonin inverse agonist (SSIA), pimavanserin is a new class of antipsychotic
medication with a distinct mechanism of action targeting serotonergic 5-HT2A receptors while avoiding activity at dopamine and other receptors commonly targeted by other antipsychotics
The study led by Coventry University found no overall reduction in the prescribing of antipsychotics
to dementia patients in UK care homes between 2009 and 2012.
polypharmacy is more widespread in Asia (32%) and Europe (26%) than in North America (16%).
Clozapine, the first atypical antipsychotic
agent, is the medication of choice when TRS is confirmed, and many studies have demonstrated its superiority over other antipsychotic
compounds in such cases (6-8).
Even with the public health advisories of the FDA, the quantity of antipsychotic
medication use is still a concern as the national rates of antipsychotic
use remain high (Kales et al.
sup] However, little is known about how antipsychotic
medications are used over time in the treatment of depression in China where the mental health system is not only fundamentally different from other countries but has undergone rapid changes in the last decade.
The Department of Health & Human Services should do more to curb antipsychotic
use in older adults with dementia, according to a recent report by the Government Accountability Office.
Little evidence has been provided regarding comparison of the stroke risk between the two antipsychotic
The chapter on the production, distribution, and regulation of antipsychotics
includes discussion of the use of antipsychotics
in nursing homes.