Sesquiterpene lactones are a large group of molecules with several biological activities and uses for humans, including antiin-flammatory, anticancer, antimicrobial, and antiprotozoal
(Tiuman et at.
The potent leishmanicidal activities of certain chemically defined molecules isolated from natural sources have become increasingly important in the search for new antiprotozoal
agents at a time when there is an urgent need for a new group of innovative medicines.
In this context, the compounds (-) mammea A/BB (1) and 5,7-dihydroxy-8-(2-methylbutanoy1)-6-(3-methylbuty1)-4-phenyl-chroman-2-one (3) are potential candidates for further research to develop new antiprotozoal
drugs, considering their significant antileishmanial activity that may act in depolarization of the mitochondria] membrane potential cells, leading to death of the parasite.
In vitro antiprotozoal
and cytotoxic activities of some alkaloids, quinones.
The broad-spectrum antimicrobial activity of TTO is mainly attributed to terpinen-4-ol and 1,8- cineole, major components of the oil, and includes antibacterial, antifungal, antiviral, antiprotozoal
and antimycoplasmal activities, all promoting TTO as therapeutic agent (Furneri et al.
MarquisA (ponazuril) Antiprotozoal
Oral Paste, marketed in North America for over a decade, treats equine protozoal myeloencephalitis (EPM) a disease that affects the central nervous system in horses.
Moreover, the choice of antiprotozoal
agents is influenced by factors other than effectiveness, such as drug availability and cost, which differ from country to country.
If the cause is giardiasis, antiprotozoal
drugs will be prescribed.
Identifying species of freshwater plants that possess bioactive compounds for various activities, they cover antimicrobial, antiprotozoal
, antihelmintic, antiviral, anticancer, antioxidant, anti-inflammatory and analgesic, antibiabetic, anticoagulant, central nervous disorders, and miscellaneous compounds.
Like other ergosterol - synthesis inhibitors, posaconazole was particularly promising because it showed antiprotozoal
activity It also has been used to treat invasive fungal infections and has an established safety profile in humans.
These include its antiinflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antifertility, ant diabetes, antibacterial, antifungal, antiprotozoal
, antiviral, antifibrotic, antivenom, antiulcer, hypotensive and hypocholesteremic activities [20-22].
TTO has antiviral, antifungal, antiprotozoal
, and antibacterial activity, according to the review.
Assessment of the antiprotozoal
activity of Galphimia glauca and the isolation of new norsecofriedelanes and nor-friedelanes.
activities of phospholipids analogues.
activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum.