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31 -- Direct coombs test -- -- Negative -- Anti-HAV -- -- Negative -- Anti-HBC -- -- Negative -- HBsAg -- -- Negative -- Anti-HBs -- -- Negative -- Anti-HCV -- -- Negative -- Anti-AMA <1/20 -- Negative -- ALP = alkaline phosphatase; ALT = alanine aminotransferase; anti-AMA = antimitochondrial antibodies, anti-HAV = hepatitis A virus antibody; anti-HBs = hepatitis B surface antibody; anti-HBV = hepatitis B virus antibody; anti-HCV = hepatitis C virus antibody; AST = aspartate aminotransferase; GGT = A-glutamyltransferase; HBsAg = hepatitis B surface antigen
Protein electrophoresis, antistreptoly-sin-O-titer, complement C3 and C4, circulating immune complexes, antinuclear antibodies, p- and c-antineutro-phil-cytoplasmic antibodies, antimitochondrial antibodies, and antiacetylcholine-receptor antibodies were negative and/or normal.
Antimitochondrial antibodies, normally found in about 95% of patients with PBC, were found in 84 of the PBC patients.
The idea was to determine whether the candidate compounds produced the highly disease-specific antimitochondrial antibodies characteristic of the disease.
The following studies were negative: hepatitis A, B, and C profiles; p-antineutrophil cytoplasmic antibodies, c-antineutrophil cytoplasmic antibodies, antimitochondrial antibodies, anti-nuclear antibodies, anti-smooth muscle antibodies, and [alpha]-fetoprotein; febrile agglutinins for Francisella, Brucella, Proteus, typhoid, and paratyphoid; serology for Aspergillus, Blastomyces, Histoplasma, Coccidioides, Leptospira, Coxiella burnetii, Toxoplasma, and Schistosoma.