of ammonium sulfate precipitates of crude protein obtained from NK 127 was assayed against clinical isolates (Shigella spp, Salmonella spp, Staphylococcus aureus, Escherichia coli and Streptococcus spp).
Ashland has released several new products including Nuosept 498G preservative, a globally accepted, 20 percent BIT-based product, and Nuospet BIC preservative, a water-based formaldehyde-free product with three active ingredients, BIT, IPBC and CMIT, that work to provide protection across a wide antimicrobial spectrum
This action mechanism gives it a bactericidal effect, with a broad antimicrobial spectrum
against both Gram-positive and Gram-negative bacteria [6,7].
002 20 13 Legend: + = Growth (turbidity) 0 = No Growth (no turbidity) Table 7 Some FDA Requirements for Characterization of An Antimicrobial Agent Deployed in a Device Identity of the agent and basic properties Concentration in the advice Method used to deploy the agent to the product Release Kinetics for the agent Antimicrobial spectrum
Mechanism of action Minimum effective concentration (MEC) (MIC) Biocompatibility Microbial test methods: organisms, inoculation and recovery procedures CDRH Guidance Draft Document, FDA, 19 July 2007.
Intravenous agents with a wide antimicrobial spectrum
and good penetration to the central nervous system (such as vancomycin, metronidazole, or cefotaxime) should be used.
They have a broad antimicrobial spectrum
, favourable pharmacokinetic profile, low incidence of side-effects, and are relatively cheap.
Psoriasin's antimicrobial spectrum
showed a strong preference for E.
The antimicrobial spectrum
of reuterin includes both Gram-positive and Gram-negative bacteria.