, and conjunctival limbal autograft have been proposed for treating recurrent pterygium.
5% Table 3 Immunosuppressive drugs Table 3 Class Examples Antimetabolites
Azathioprine Methotrexate Mycophenolate mofetil Alkylating agents Cyclophosphamide Chlorambucil Antibiotics Cyclosporine Tacromimus Rapamycin Dapsone Adjuvants Bromocriptine Ketoconazole Colchicine
The recommended initial measure is the reduction of immunosuppression, which was performed in 100% of the patients we reported here and which consisted of anticalcineurin suspension in all of them, and antimetabolite
in the majority, with change to everolimus or sirolimus.
A successful case of trabeculectomy without adjunctive antimetabolites
performed with retrobulbar anesthesia has been reported in a pregnant patient.
therapy is often administered concomitantly to prevent antichimeric antibody production.
This study provides a new understanding of an unexplored antimetabolite
, L-CAV as an alternative of classical antimetabolites
, such as 5-fluoruracil and methotrexate.
Rosenbaum will quickly switch to an antimetabolite
, with methotrexate his top choice.
MTX is an antineoplastic antimetabolite
with immunosuppressant actions.
A potent antimetabolite
is 5-fluorouracil (5-FU) that acts during the S phase of the cell cycle.
Exclusion criteria included eyes with uveitis, rubeotic eyes, and eyes which have had previous intraocular surgery or in which antimetabolite
supplementation was to be used, the only demonstrable risk factor for failure in our patients was the prior use of topical anti-glaucoma medications and the two groups were selected keeping the factor distributed symmetrically.
Hydroxyurea: a new antimetabolite
in the treatment of psoriasis.
Cytarabine is a cell cycle-specific (S phase) antimetabolite
that inhibits DNA synthesis.
The ability of CD to convert nontoxic 5FC into toxic 5FU antimetabolite
and its absence in mammalian cells has been exploited in enzyme-prodrug gene therapy and shown to control tumour growth (Hamaji et al.
Methotrexate is an antimetabolite
which impairs DNA synthesis by competitively inhibiting folic acid metabolism.
drugs such as gemcitabine (GEM) and 5-fluorouracil (5FU) are approved for the treatment of pancreatic cancer; however, upon treatment tumor cells develop resistance against these agents rendering them ineffective (Shore et al.