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Nevertheless, since then, published reports from various medical fields, including dermatology (37), gynecology (38), and oncology (26), have collectively indicated that increased endogenous folate concentrations may indeed a priori neutralize the antimetabolic effect of MTX.
The anti-neoplastic agent can be an alkylating agent, an antibiotic agent, an antimetabolic agent, a retinoid, a hormonal agent, a plant-derived agent, an anti-angiogenesis agent and a biologic agent such as monoclonal antibody and interferon.
Roobol C, Sips HC, Theunissen J, Atassi G, Bernheim JL (1984) In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays.
In rats fed with experimental diet T2 containing raw SB seeds, a part of the protein supplied might be rerouted for the synthesis of digestive enzymes such as trypsin and chymotrypsin to offset the effects of various antimetabolic substances present in the raw SB seeds.
More specifically, the many antimetabolic tropes of King John condense and translate for auditors and readers the various mirrorings and impasses of this chronicle history that help create its characteristic indeterminate meaning.
DPD is also the principal enzyme involved in detoxification of pyrimidine-based antimetabolic analogs, such as 5-fluorouracil (5-FU), a drug that is commonly used in the treatment of solid tumors (colon, breast, head, neck, ovary, and skin).