If the antigen-presenting cells
produce the peanut protein robustly enough, the responsibility for the immune response might shift away from the IgE antibodies and mast cells.
When they analyzed "gene chips" to screen the disease-causing antigen-presenting cells
recovered from lungs with emphysema, they uncovered the gene for osteopontin, which promotes initiation of the inflammatory cascade that damages lungs.
Based on Iomai's novel transcutaneous immunization (TCI) technology, the patch works by delivering vaccine to a group of antigen-presenting cells
in the skin called Langerhans cells, which transport the vaccine to nearby lymph nodes to produce a sustained immune response.
Scientists consider dendritic cells to be the most potent antigen-presenting cells
in the body.
The paper, "Recruitment of Antigen-Presenting Cells
to the Site of Inoculation and Augmentation of HIV-1 DNA Vaccine Immunogenicity by In Vivo Electroporation", was published online ahead of print at the Journal's web site http://jvi.
The researchers found that one TLR, known as TLR8, triggered a strong immune response in antigen-presenting cells
, which are crucial for vaccine responses.
A patrolling T cell might then encounter one of these antigen-presenting cells
Abstract #1035: "Immunosuppressive properties of soluble extracellular domain of CD83 on antigen-presenting cells
of cynomologous monkey"
enzymatic activity), resistance to proteolytic digestion, overall immunogenicity and the way in which the protein is recognized, internalized, and processed by antigen-presenting cells
, and the manner in which peptides are presented to responsive T lymphocytes (Aalberse 2000; Astwood et al.
If the part of HIV that is similar to the antigen-presenting cells
were used as a vaccine, the antibodies generated against the vaccine material would also be capable of attacking the antigen-presenting cells
The Duke clinical trial uses an ex vivo (outside the body) process in which dendritic cells (the most efficient antigen-presenting cells
in the body) are isolated from the patient's blood, pulsed with telomerase RNA, and then used to vaccinate the patient.
The role of antigen-presenting cells
in the regulation of allergen-specific T cell responses.
He also found that Plasmodium GPI would hyperactivate macrophages and antigen-presenting cells
in the immune system, and cause red blood cells to adhere to blood vessels--all conditions associated with deadly cerebral malaria.