Age, gender, marital status, previous obesity history, hypertension, dyslipidemia, smoking, hypothyroidism and antidiabetic drug
usage in diabetic subjects were found to be significant risk factors for obesity development.
PIONEER 10 was a 57-week, randomised, open-label, active-controlled, parallel-group, multi-centre, single country trial with four treatment arms, comparing the safety, tolerability and efficacy of 3, 7 and 14 mg oral semaglutide with 0.75 mg dulaglutide (the approved dose by the Pharmaceutical and Medical Devices Agency (PMDA) in Japan) in Japanese people with type 2 diabetes inadequately controlled with one oral antidiabetic drug
(sulfonylurea, glinide, thiazolidinedione, alpha-glucosidase inhibitor or sodium glucose cotransporter-2 inhibitor).
* Previously receiving at least one oral antidiabetic drug
(metformin or sulfonylurea) or dual-combination therapy (metformin + sulfonylurea) and for the first-time initiated on a second-line add-on agent, i.e., pioglitazone or DPP-4 inhibitor (sitagliptin/vildagliptin) or [alpha]-glucosidase inhibitor (voglibose) or insulin (pre-mixed insulin [30% regular/70% NPH]).
The safety and effects of newly licensed antidiabetic drugs
on the cardiovascular system represent important clinical issues [6,7].
A subgroup of patients who were using thiazolidinedione alone or in combination with other antidiabetic drugs
High-dose MFDT (group D) showed similar results to glibenclamide, a standard antidiabetic drug
(group E), in all parameters except in TC which did not significantly decrease as opposed to the untreated group F.
 (2016) Trends of 2002-2013 antidiabetic drug
use in adult Type 2 diabetes in Korea in 2002-2013: nationwide population-based cohort study Ou et al.
It is worth noting that these different results from different studies may be attributable to the fact that the gut microbiome composition can change rapidly during the course of treatment with antidiabetic drug
, such as metformin, which has not been accounted for in many studies.
In the setting, no similar study has been carried out to establish the prescription pattern of antidiabetic drugs
among type 2 diabetics.
These guidelines recommend that the prescribed dosage of several oral antidiabetic drugs
(OADs) should be altered or avoided in patients with diabetes and comorbid CKD .
Two-dimensional hierarchical clustering of target profiles was used to determine possible antidiabetic ingredients by comparing the GGQLD ingredients and antidiabetic drug
Selection was realized through the database and were included all patient of the district mentioned above who received at least one of the oral antidiabetic drug
(OAD) (glibenclamide 5mg; metformin 850mg; gliclazide 80mg) or insulin from Brazilian Public Health System between March 2006 and February 2007.
According to MacLean, a final piece of evidence indicating that obesity and overfeeding during the menopausal transition converge to promote tumour growth and progression was that the antidiabetic drug
metformin reduced tumour burden in obese rats after surgical ovariectomy.
After reviewing the data, they compared groups treated either with a placebo or with another antidiabetic drug
The effects were compared with glibenclamide (GLB) (2.5 mg/kg), a standard antidiabetic drug
of the sulfonylurea class.