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Low trough levels are associated with loss of response, likely by favoring antibody formation.
This was not surprising, because when a substance is taken in through the lung the immune system reacts in a Th2 fashion, favoring antibody formation," he said.
The potential for antibody formation with the use of BOTOX(R) may be minimized by injecting with the lowest effective dose given at the longest feasible intervals between injections.
There are, however, vaccines available that cause antibody formation against the hepatitis B virus in 90 to 95 percent of those vaccinated.
The issue of prevention of antibody formation against the biologic agent is particularly important but elusive to determine due to the lack of standard laboratory assays which can be used in clinical practice to determine their presence.
We have already made progress in identifying potential options to reduce antibody formation and will continue to work with the FDA on plans to move the IB1001 program forward.
Antiexenatide antibody formation, seen in 67% of exenatide LAR-treated patients at week 15, was not predictive of end point response or adverse safety outcome.
While the preliminary clinical trial did not test whether the vaccine can prevent infection, it did determine that the vaccine leads to antibody formation against rotaviruses, with few side effects.
It is estimated that more than 50% of chronically transfused patients will develop an alloantibody, versus about 2-4% antibody formation rate for the general population.
The PR1 peptide was designed to be small enough so that it would not trigger antibody formation, Dr.
Thus far, researchers have induced antibody formation in goats, rabbits, mice and guinea pigs.
The authors concluded that RECOTHROM is a well-tolerated topical hemostatic agent in numerous surgical settings and has a low rate of anti-product antibody formation.
Like natural viruses (which can be made of single- or double-stranded DNA or RNA), double-stranded RNAs can induce antibody formation, interferon production and activation of macrophages and natural killer (NK) cells, two types of immune system cells that fight off viral infections and tumors.
The FDA-approved prescribing information for topical bovine thrombin notes that the risk of antibody formation increases with multiple exposures, and that patients with pre-existing antibodies to bovine thrombin preparations should not be re-exposed to these products.