Under a collaboration agreement Merck established with Abmaxis in late 2004, Abmaxis successfully re-engineered a Merck human monoclonal antibody and improved antibody affinity
more than 70-fold while retaining its specificity.
The patent pending ProteoPrep 20 Kit removes 99% of twenty high abundant plasma proteins using a proprietary multivalent antibody affinity
media in a convenient spin column format resulting in removal of 97% of the overall protein mass.
Three primary applications are currently available for antibody characterization using the 8500 system: antibody affinity
determination, identification of matched antibody pairs, and peptide epitope mapping.
The Abmaxis team has successfully re-engineered Merck's human monoclonal antibody and improved antibody affinity
more than 70-fold while retaining its specificity, triggering a milestone payment from Merck.
The invention described in this patent outlines a very powerful application of our MORPHODOMA(R) process to generate genetic diversity within an existing antibody cell line to further optimize antibody affinity
and/or the host cell line's productivity," added Dr.
The ability to generate high affinity antibodies is important because for many targets of antibody therapy, high antibody affinity
is closely linked to therapeutic potency.