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In an in vivo model of lung cancer metastasis in which tumor cells from an intravenous injection migrate to, attach and grow in lung tissue, multiple doses of GRN163L over a three-week period from the time of animal inoculation with A549-luc tumor cells resulted in significant reduction in tumor progression.
Immediately before animal inoculation, aliquots of the clinical and control urine pools were thawed and sonicated on ice with separate sterile ultrasonication probes for each pool.
In an in vivo model of lung cancer metastasis, in which tumor cells from an intravenous injection migrate to, attach and grow in lung tissue, a single dose of GRN163L at the time of animal inoculation with A549-luc tumor cells resulted in significant reduction in tumor burden at days 13, 20 and 27 of tumor progression.
Isolation of this rickettsial agent from the patient's blood by animal inoculation and by cell culture methods is ongoing.
OTCBB:MDIR), a developer and marketer of patented needle-free jet injectors for human and animal inoculation, today announced that on September 15th, 2004, the Japanese Ministry of Agriculture, Fishery and Forestry (MAFF) has endorsed its needle-free injection technology and has granted MIT's Japanese Distributor "Frontier International Co.