What the data show is evidence of linkage of the angiotensinogen
gene to human essential hypertension," Caulfield says.
The Cambridge findings unexpectedly revealed a fine-tuning mechanism in angiotensinogen
that is responsive to changes in tissue oxygen.
A guanine (G) to arginine (A) switch at position 6 in the angiotensinogen
gene correlated strongly with pressure response in the DASH cohort.
The observed metabolic response to exercise is related to the rise in glucagon, growth hormone, catecholamines, prolactin, adrenocorticotropic hormone (ACTH), cortisol, luteinizing hormone, progesterone, antidiuretic hormone (ADH), angiotensinogen
, aldosterone, renin, atrial natriatic factor, thyroid stimulating hormone (TSH), thyroid hormones ([T.
and French researchers targeted a gene that codes for a protein called angiotensinogen
(AGT), an important raw material in the chemical process that regulates blood pressure.
Despite their great efficacy in treating these inflammatory conditions, these antibodies have proved unsuccessful in treating obesity-related inflammation and type 2 diabetes (9,10), perhaps because obesity-induced inflammation in humans is a more complex process that involves cytokines and chemokines other than TNF-[alpha], such as adiponectin, leptin, IL-6, resistin, monocyte chemoattractant protein 1, plasminogen activator inhibitor 1, angiotensinogen
, visfatin, retinol-binding protein 4, serum amyloid A, and many others.
Recurrent in-stent restenosis is not associated with the angiotensin-converting enzyme D/I, angiotensinogen
Thr174Met and Met235Thr, and the angiotensin-II receptor 1 A1166C polymorphism.
High sodium intake strengthens the association between angiotensinogen
T174M polymorphism and blood pressure levels among lean men and women: a community-based study.
University of Southern California (Los Angeles, CA) has patented methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen
, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II analogues, AII fragments or analogues thereof or AII AT.
Estrogen has been shown to decrease tissue angiotensinogen
gene expression in ovariectomised Sprague-Dawley rats and to reduce ACE mRNA concentration and tissue ACE activity.
Common hypertension-causing drugs Medication Mechanism of action Management Steroids Corticosteroids Increases sensitivity to Discontinue drug, fluid catecholamines restriction, diuretics Mineralocorticoids Increased exchangeable Discontinue drug, fluid sodium and blood volume restriction, diuretics Sex hormones Sodium retention, volume Discontinue drug, fluid expansion, increased restriction, plasma concentration of diuretics angiotensinogen
Immunosuppressive agents Cyclosporine Enhanced renal Discontinue or switch vasoconstriction, to tacrolimus.
Therapeutic use: Aliskiren (1-3) is a direct renin inhibitor that decreases plasma renin activity and inhibits the conversion of angiotensinogen
to angiotensin I.
Renin cleaves an inactive peptide called angiotensinogen
, converting it into angiotensin I, which travels in the circulation to the lung capillaries where it is converted to angiotensin II (AII).
Although hundreds of genes differed between the control- and alcohol-fed rats, the authors noted with interest that the expression of angiotensinogen
and angiotensin converting enzyme (ACE), which are key components of the renin-angiotensin system,?
Another study of ten polymorphisms in nine genes found a strong association between a specific angiotensinogen
haplotype and genetic susceptibility to PE (14).