2009) Influence of angiotensinogen
and angiotensin-converting enzyme polymorphisms on cardiac hypertrophy and improvement on maximal aerobic capacity caused by exercise training.
For the PRA assay, analytical sensitivity can be improved by increasing the duration of the incubation step during which angiotensin I is generated (and directly measured) from cleavage of endogenous angiotensinogen
Renin is an aspartyl protease which specifically cleaves angiotensinogen
Renal damage inhibited in mice lacking angiotensinogen
gene subjected to unilateral ureteral obstruction.
Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen
gene polymorphisms in hypertensive disorders of pregnancy.
235T allele "dosage" is associated with blood pressure phenotypes.
When a fall in blood pressure is detected by the juxtaglomerular cells in the kidney, renin is released, which reacts with angiotensinogen
in circulating blood to convert angiotensin to angiotensin I.
2) The adipocytes behave as an endocrine cell and release numerous molecules including Angiotensinogen
and Cytokines which in turn activate rennin-angiotensin-aldosterone axis and Sympathetic Nervous System.
Strong and independent association between angiotensinogen
gene polymorphisms and hypertension in 10060 patients with stable coronary artery disease.
Study co-authors for "Fruits and Vegetables or Oral NaHCO3 Preserve GFR and Reduce Urine Angiotensinogen
, a Marker of Kidney Angiotensin II Activity, in Stage 3 CKD" include Chanhee Jo, PhD, Jan Simoni, PhD, and Donald E.
It has been demonstrated that maternal salt loading during pregnancy induces changes in angiotensinogen
mRNA in the foetal liver and brain (Mao et al.
TrainingInduced Pressure Fall in Spontaneously Hypertensive Rats Is Associated With Reduced Angiotensinogen
mRNA Expression Within the Nucleus Tractus Solitarii.
Agachan B, Isbir T, Yilmaz H, Akoglu E: Angiotensin converting enzyme I/D, angiotensinogen
T174M-M235T and angiotensin II type I receptor Al166C gene polymorphisms in Turkish hypertensive patients.
Moreover, unlike the systemic RAS, where renin secretion by the kidney plays an important regulatory role in the processing of angiotensinogen
, it is not clear how the production of angiotensin II by the tissue RAS is controlled.
The classical pathway involves activation of angiotensinogen
to angiotensin I by renin, and conversion of angiotensin I to angiotensin II by angiotensin-converting enzyme (ACE).