Sensorineural hearing loss in diabetic patients is caused by cochlear angiopathy
characterized by dilatation of the blood vessels of the stria vascularis, atrophy, and loss of outer hair cells.
A beta is one of the main components of the pathological hallmarks that are commonly observed in AD, such as senile plaques and cerebral amyloid angiopathy
. A beta itself has been reported to have toxic effects on neurons.
She had spent nearly a month in the neuro ICU before succumbing to a rare illness called cerebral amyloid angiopathy
The differential diagnosis includes diabetic angiopathy
, embolic disease, atherosclerosis, hypercoagulability/thrombophilia, vasculitis or connective tissue diseases, and drug-associated (eg, cocaine) vasculitis.
Cerebral amyloid angiopathy
(CAA), a buildup of amyloid proteins on the brain artery walls, is a cause of intracerebral hemorrhage.
Higher prevalence of 18.1% have been reported in a study conducted in Sudan27 and 16% in a study conducted locally in Pakistan by Niaz et al.22 The lower prevalence rates ranging from 0.8%-3% are reported by different studies from India and Pakistan.14,21,24 Neuropathy and angiopathy
along with impaired immunity, venous insufficiency and lymphedema are the different mechanisms contributing in development of diabetic foot.
presenting with multifocal conduction blocks.
Hereditary cerebral amyloid angiopathy
is caused by COL4A1/COL4A2 mutation (7,8), and CARASIL by the high temperature requirement protease A1 HTRA1 allele mutations, which is also called HTRA1 homozygous mutations (9-13).
Results: In recent years, studies have demonstrated that hypertension-related changes (e.g., small vascular lesions, inflammatory reactions, hypoperfusion, oxidative stress, damage to autoregulatory processes and the blood-brain barrier, and cerebral amyloid angiopathy
) can occur over time in cerebral small vessels, potentially leading to lower cognitive function when blood pressure (BP) control is poor or lacking.
Susac syndrome, usually seen in young females, is an angiopathy
of unknown etiology that presents with various signs including ataxia, vertigo, pyramidal signs, and epileptic seizures due to extensive white and gray matter involvement.
"This study provides strong, if circumstantial, evidence for an association between neurosurgery in childhood and the development in late adult life of cerebral amyloid angiopathy
(CAA)," said Robert Howard, a clinical psychiatrist at University College London, using the clinical name of the disease caused by the protein.
Primary intracerebral hemorrhage (pICH) is a non-traumatic hemorrhage in the brain parenchyma and/or chamber system, most commonly from small blood vessels due to chronic hypertension or cerebral amyloid angiopathy
Though hypertension and cerebral amyloid angiopathy
contribute to the vast majority of ICH incidence, in recent times, the anticoagulant therapy has been recognized as a small but significant avoidable cause of ICH.
CAPS is a rare life-threatening form of APS in which thrombotic angiopathy
results in multiple organ dysfunction .
 reported that angiopathy
represented by a thickened basement membrane was observed in the dental pulp of diabetics.