hamartomas occur predominantly on the lower extremities as a pink-red patch or thin plaque, from 1 to 10 cm in diameter.
Although caruncles are usually benign, they should be surgically excised and histopathologically examined since they may be the indicators of lymphoma, clitoral venous thrombosis, urethral thrombosis, pseudoneoplastic lesions, urethral polyps, malign melanoma, intestinal heterotypic, angiomatous
lesions, and diastolic urethral stenosis (5,6,7,8,9,10,11).
Clear cell meningiomas are more frequently associated with mutations of SMARCE1, a regulator of cellular growth and proliferation, including the arachnoid location, being different from angiomatous
genotype which is characterized by multiple chromosomal polysomies, without NF2 mutations [3, 72, 73].
Patients with SWS but without the facial angiomatous
lesion, which is the most frequent finding in SWS, have been reported in the literature (3).
Inflammatory polyps, benign and malignant vascular malformations, and angiomatous
variants of Kaposi sarcoma have been considered in the differential diagnosis of PGs.
Caption: Figure 8: Postmortem finding: mucin-filled alveoli surrounded by angiomatous
features of Kaposi sarcoma.
Histologically speaking, it is most commonly due to plexiform angiomatous
lesions in the arterial media that thicken the arterial wall and concomitantly reduce its compliance.
Additional subtypes of nAMD, such as polypoidal choroidal vasculopathy (PCV) and retinal angiomatous
proliferation (RAP), were further detailed with the development of optical coherence tomography (OCT).
In spite of strict oral hygiene measures, angiomatous
gingival enlargement poses a threat to gingival health and may at some point require gingivectomy.
(5), there may be five alternatives: teratoid origin coupled with significant overgrowth of the myomatous elements, smooth muscle cells that migrate from the nipple during embryological life, a multipotent mesenchymal cell, angiomatous
smooth muscle and myoepithelial cells.
The term "pseudoangiomatous" describes the histological pattern which resembles an angiomatous
One of them, Eccrine Angiomatous
Hamartoma (EAH), contains numerous capillary channels as well as small nerves and sometimes mucin, fatty tissue and pilar structures in between sweat gland coils, which may explain the pressure sensitivity seen in these lesions .
Valsalva-related preretinal hemorrhages are commonly caused by macroaneurisms, and subretinal hemorrhages are commonly seen in choroidal neovascularizations and especially in cases with retinal angiomatous
Other GI manifestations of NF-1 in patients listed in Table 1 included one or multiple small-bowel GISTs (two patients), duodenal somatostatinoma (one patient), duodenal hyperplastic-inflammatory polyp (one patient), interstitial cell of Cajal hyperplasia (one patient), cecal inflammatory polyp (one patient), and angiomatous
colonic polyp (one patient).