Because Sema3A and Sema3F are well known as angiogenesis inhibitors
, these two proteins were used for comparative monitoring of Sema3C effects on the microcapillary tube formation.
Investigation of hundreds of potential angiogenesis inhibitors
resulted in the approval of bevacizumab (VEGF neutralizing antibody) by the U.S.
Matsushima et al., "Lenvatinib, an angiogenesis inhibitor
targeting VEGFR/FGFR, shows broad antitumor activity in human tumorxenograft models associated with microvessel density and pericyte coverage," Vascular Cell, vol.
Bevacizumab is the first approved angiogenesis inhibitor
that was shown to slow tumor growth and, more importantly, to extend the lives of patients with some cancers.
A once-daily oral medication, Votrient is an angiogenesis inhibitor
that may help prevent the growth of new blood vessels, thereby blocking the growth of kidney cancer tumors that need blood vessels to survive.
"Scientists have reported results from a clinical trial in which a subset of patients developed tumor recurrence at many sites during the course of treatment with bevacizumab [Avastin], an angiogenesis inhibitor
. The recurrence was measured by MRI imaging."
Scientists made the discovery after studying cilengitide, an experimental angiogenesis inhibitor
which has not yet been licensed for patients.
The angiogenesis inhibitor
, bevacizumab, as well as the EGFR inhibitors, have clearly increased the therapeutic armamentarium for patients with metastatic CRC.
The first oral angiogenesis inhibitor
for cancer, sorafenib (Nexavar[R], Onyx Bayer), was not included in the table.
Roberts et al (16) have identified components downstream of NO as the primary target of the endogenous angiogenesis inhibitor
thrombospondin-1 and have shown that circulating levels of thrombospondin-1 are sufficient to limit angiogenic responses by antagonizing NO signalling.
Tokyo, Japan, Mar 31, 2006 - (JCN) - OncoTherapy Science and Fuso Pharmaceutical Industries jointly announced on March 29 that the Pharmaceuticals and Medical Devices Agency (PMDA) has accepted a notification of the phase I clinical trial plan of OTS102, an angiogenesis inhibitor
currently under development by OncoTherapy Science.
Celebrex, a cyclooxygenase-2 inhibitor, apparently increases the production of thrombospondin, a natural angiogenesis inhibitor
, said Dr.
The expression of a 517-bp transcript was potentially decreased by both 1 nM and 1 [micro]M OP and was 59% identical to human brain-specific angiogenesis inhibitor
Angiogenic macrophages produce the angiogenesis inhibitor
Bevacizumab is a recombinant humanized monoclonal antibody and in 2004 it became the first clinically used angiogenesis inhibitor