Keywords: 1-Monocaproin; Chorioallantoic membrane assay; Vascular endothelium growth factor; Angiogenesis
Hypoxic adaptations are attributed to increasing glucose transportations, glycolysis, especially, angiogenesis
. The formation of new blood vessels necessitates VEGF, fibroblast growth factor, angiogenin, etcetera, which are modulated by HIF-1.9-11 HIF-1 is thought to be critical mediator of the transcriptional response to hypoxia and the expression of HIF-1a, the main activity unit, is regulated by oxygen availability.3,14
Authors concluded the results to demonstrate that hyperforin promotes angiogenesis
and functional recovery after stroke through IL-17A-mediated elevation of VEGF expression.
Currently, members of the VEGF family and their receptors have been recognized as mediators of angiogenesis
. The binding of VEGF to their receptors situated on endothelial cells induces chain reactions that are mostly mediated by MAP kinase and PI3K/Akt/mTOR .
Thus, in the present study, zebrafish was used as an in vivo model to study the role of Bach1b in Wnt/[beta]-catenin signaling and the developmental angiogenesis
, and in vitro cell transfection and chromatin immunoprecipitation (ChIP) assays were conducted to elucidate how Bach1 regulates Wnt target gene (VEGF) expression in human umbilical vein endothelial cells (HUVECs).
This is an in ovo angiogenesis
assay for identification and quantification of anti-angiogenic agents.
Dado esto, es interesante caracterizar agentes que participan en la modulacion de este proceso de angiogenesis
In the present study, we investigated gene expression levels of vascular endothelial growth factor (VEGF), one of the main angiogenesis
stimulating factors, and thrombospondin-1 (TSP-1), which is an angiogenesis
suppressing factor, in tumor tissues obtained from patients with bladder cancer.
The study found that lowering FoxO1 levels promoted angiogenesis
and caused a healthier adipose tissue -- in particular, with a high-fat diet.
In addition, Sema3 regulate processes such as tumor growth, metastatic spread (2,3), and tumor-associated angiogenesis
inhibition by interacting with vascular endothelial growth factor (VEGF) signaling pathway components (4,5).
For example, the association between an increased expression of COX-2 and tumor angiogenesis
(20) and the antiangiogenic effects of COX-2 inhibition by CX, mediated through the inhibition of VEGF expression, has been previously demonstrated.
 During the specifically ordered process of natural formation of blood vessels, the endothelial cellules receive stimuli from the angiogenesis
and secrete special enzymes such as matrix metalloproteinases and heparinizes.
As an essential part of biological substrates for poststroke brain remodeling, angiogenesis
induced by brain ischemia enhances blood flow and nutrient supply to the affected tissue, which may benefit functional recovery [2, 3].
is the physiological process through which new blood vessels form from preexisting vessels [1, 2].
is the formation of new capillaries by outgrowth of endothelial cells from preexisting blood vessels (7).