Gores, "Constitutive androstane
receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse," World Journal of Gastroenterology, vol.
A significant correlation has been found between hepatic CYP2E1 activity and nocturnal hypoxia. We had previously reported that rats exposed to IH and cigarette smoke exhibited an increase of hepatic inflammatory cytokines, a reduction of CYPs, and a decrease of the nuclear receptors pregnane X receptor (PXR), constitutive androstane
receptor (CAR), and glucocorticoid receptor (GR). Therefore, we hypothesized that IH-associated inflammation will independently lead to liver injury, which may further be exacerbated by another hepatic insult.
And the nuclear receptor CAR (Constitutive Androstane
Receptor) is mainly expressed in liver, where it is activated by structurally diverse ligands and then regulates cytochrome P450 and other genes whose products are involved in DMEs and transporters (Tien and Negishi, 2006; Osabe et al., 2009; DeKeyser and Omiecinsk, 2010).
Appanna, "Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane
receptor and the estrogen receptor alpha," PLoS ONE, vol.
Chen et al., "Methylation of the constitutive androstane
receptor is involved in the suppression of CYP2C19 in hepatitis B Virus-associated hepatocellular carcinoma," Drug Metabolism and Disposition, vol.
(22.) Shankar MB, Parikh JR, Geetha M, Mehta RS, Saluja AK, Antidiabetic activity of novel androstane
derivatives from Syzygium cuminii Linn.
In his UFC 183 win over Nick Diaz, Silva failed the pre-fight drug tests for anabolic steroids Drostanolone and Androstane
, and even the post-fight test for Drostanolone plus sleeping and anti-anxiety medication.
One of these receptors, the nuclear receptor subfamily 1, group I, member 3 (NR1I3, also known as the Constitutive Androstane
Receptor, CAR), is an orphan nuclear receptor that was first characterized as a cell "xenosensor," and considered a master regulator of drug metabolism and excretion (1).
The study suggests triclosan may do its damage by interfering with the constitutive androstane
receptor, a protein responsible for detoxifying (clearing away) foreign chemicals in the body.
causes receptor-mediated upregulation of ATP-driven xenobiotic efflux transporters at the blood brain barrier , while blood brain barrier flux of aluminum, manganese, iron, and other metals is suspected to contribute to metal-induced neurodegeneration (Tables 1 and 5) 36].
Compounds RSD (a) LODs (b) Linear Regression r (%) (ng/L) range equation (n = 5) (ng/L) n[C.sub.17] 3.6 0.2 10-800 y = 0.0018 0.9998 -alkane + 0.0132x Pristine 5.1 0.5 10-800 y = 0.0105 0.9993 + 0.0267x Naphthalene 78 1.6 10-500 y = 0.0237 0.9965 + 0.0087x 5-[alpha]- 4.6 0.8 10-500 y = 0.0138 0.9971 Androstane
+ 0.0032x (a) The concentration of the standard solution was 50 ng/L for each compound.
The surrogate spiking standards were 5-alpha androstane
(Part # GRH-IS-10X, AccuStandard) and 10 mg of phenanthrene-[d.sub.10] neat (Part # 364622, Sigma-Aldrich, St.
Knorozova, "Synthesis of derivatives of the androstane
nthesis (1970) 3-Chloro-l 7-aziridino Semisy Langlois etal.
Entre los reguladores de este tipo mejor caracterizados se encuentran el <<pregnane X receptor>> (PXP), los <<retinoid-related orphan receptors>> (RORs), el <<constitutive androstane
receptor>> (CAR), los <<liver X receptors>> (LXRs), los <<peroxisome proliferator-activated receptors>> (PPARs) y el <<vitamin D receptor>> (VDR).