After two years of ADT, he opted for intermittent androgen suppression
and his LHRH injections were stopped.
Cost-effectiveness of androgen suppression
therapies in advanced prostate cancer.
In addition to androgen suppression
, men who were randomly allocated to the two bisphosphonate groups were given zoledronic acid for 18 months.
Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression
therapy for prostate cancer without bone metastases: a randomized controlled trial.
In a phase III study involving 1,386 men, median overall survival was 9.1 years with continuous androgen deprivation and 8.8 years with intermittent androgen suppression
(P value .009, hazard ratio 1.02), lead author Dr.
Surgery, external-beam radiation therapy, brachytherapy (implanted radiation seeds), and androgen suppression
are the primary conventional treatments for prostate cancer at this time.
It remains unclear how a lower estrogen dose affects mood in women who have a history of premenstrual syndrome and whether mood improvement with a lower estrogen dose is related to a lower degree of androgen suppression
"Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: An in vivo study using an androgen suppression
model," Journal of Cellular Physiology 205(1): 141-157.
However, because PSA synthesis and secretion require hormonal influence, androgen suppression
can reduce PSA production (4).
Various methods of androgen suppression
yield similar survival rates, but orchiectomy is cheaper and spares patients repeated hospital visits and drug-related side effects.
Intermediate-risk men who received 4 months of androgen suppression
plus radiotherapy had the most pronounced benefit, with an overall survival rate of 72% vs.
SEATTLE -- It's known that patients undergoing combined androgen suppression
therapy for prostate cancer may experience decreases in penile and testicular volume, but physicians don't always inform patients of this risk, Dr.