Acting on the knowledge that the gene polo-like kinase 1 (PLK1) can become overexpressed during ADT and that its overexpression can also stimulate androgen
synthesis, Xiaoqui Liu and colleagues tested the effects of administering the PLK1-inhibitor B12536 with low-dose metformin in prostate cancer cells.
The McMaster data presented at the 2014 meeting adds to this body of knowledge as it appears that at least part of the deleterious metabolic effects of androgen
deprivation therapy (ADT) may lie in its FSH-suppressing activity and not all due to lowering of testosterone.
XTANDI is an oral, once-daily, androgen
receptor signaling inhibitor.
com/research/djkgl4/therapeutic_class) has announced the addition of the "Therapeutic Class Overview: Newer Oral Anti Androgens
- Expanding Role in the Treatment Paradigm of Prostate Cancer" report to their offering.
Using mouse models to mimic the progression in humans, they observed how the cancer cells responded to and survived androgen
Human ovaries have insulin receptors, and in vitro studies have shown that insulin can have a direct effect on androgen
production in stroma cells of the ovaries.
Galeterone is a proprietary small molecule, oral drug for the treatment of prostate cancer that disrupts androgen
receptor signaling via a novel triple mechanism of action.
The consequences of long-term androgen
deprivation are often more striking than the positive aspects of prolonging it.
The most prominent player in the progression of AIPC is the androgen
receptor (AR), a protein that binds to androgens
and acts as a transcription factor to regulate a wide array of genes involved in various processes, including proliferation and growth (5-7).
production primarily occurs in the testes and adrenal glands; in men with prostate cancer, the tumour tissue is an additional source of androgens
receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen
In their recent comprehensive update on the molecular biology of prostate cancer, Mackinnon et al (1) refer to the interesting possibility that the significance of TMPRSS2 (transmembrane protease, serine 2) fusion genes, including the commonest type, TMPRSS2:ERG (v-ets erythroblastosis virus E26 oncogene homologue), now known to be present in at least 50% of cases, (2) may be quite different depending on the androgen
receptor status of the tumor.
Excessive and deficient androgen
levels have been linked to:
Some girls have excessive weight gain, which is difficult to lose but, if it can be lost, androgen
levels will drop and with them the amount of excessive hair.
RESULTS: We found activation of HER-2/neu oncogene in transformed CAsE-PE cells, providing molecular evidence of androgen
independence in the transformed cells.