High-grade DAs exhibit increased hypercellularity (Figure 2, C) and nuclear anaplasia
, and are mitotically active (WHO grade III) with or without palisading necrosis, endothelial proliferation, and thrombosis (glioblastoma, WHO grade IV) (Figure 2, D).
Microscopic examination of tumor mass revealed high degree of cellular anaplasia
, pleomorphism and varying degree of mitotic activity, spindle to stellate shaped cells with elongated plumpy nuclei arranged in form of interlacing bundles (Fig.
Los hallazgos de anaplasia
, invasion o de metastasis a distancia son indicativos de transformacion maligna (13, 14).
The most commonly used systems are based on the degree of anaplasia
of the tumor cells.
Features suggestive of malignancy include a tumor diameter greater than 5 cm, necrosis, hemorrhage, cellular anaplasia
, and a high mitotic rate ([greater than or equal to] 4/10 hpf).
27) Cellular anaplasia
, loss of polarity, discohesion, nuclear enlargement, hyperchromasia, pleomorphism and atypical mitoses are the histopathological hallmarks of CIS.
Microscopically; mucosa revealed diffuse urothelial dysplasia with loss of polarity, nuclear atypia; and carcinoma in situ with irregular nuclear crowding, nuclear anaplasia
and mitosis, involving entire thickness of the epithelial layer.
He describes how gene mutations are not powerful enough to cause cancer; how cancer is initiated and why progression takes years or decades; and the global or macroscopic characteristics that identify cancer: anaplasia
, autonomous growth, metastasis, abnormal cell morphology, DNA indices from 0.
The animals showed a marked degree of hyperplasia with mitotic figure in the cells of stratum granulosum of epidermis and fibrocytes of the dermis, extensive anaplasia
and malignant changes in acini and ducts of the mammary gland.
Histologically, diffuse anaplasia
, PAS positive-DR hyaline globules and variable myxoid change.
Ha elevado pleomorfismo celular e nuclear associado com intensa anaplasia
Prognostic histology may be divided into favourable histology (triphasic Wilms' tumour and cystic, partially differentiated nephroblastoma) and unfavourable histology (focal or diffuse anaplasia
, and cells that are more abnormal and appear bizarre with large and distorted nuclei).
Histologically, these tumors usually demonstrate definitive anaplasia
, although sometimes the distinction between a periosteal chondroma and low-grade chondrosarcoma is difficult or indeterminate.
with cell pleomorphism and varying degrees of mitotic activity are characteristic for all malignant variants except the dendritic and whorled types (WEISS & FRESE, 1974).
Nevertheless, a few studies have documented minor his top a tho logical differences between AIDS-associated KS and non-HIV associated KS cases [14-16]: lesional cell mitoses and cellular anaplasia
are surprisingly more common in HIV-negative patients, whereas KS lesions in HIV-positive patients tend to display more extensive dissecting vessels.