New definitions of focal and diffuse
anaplasia in Wilms tumour: the International Society of Paediatric Oncology (SIOP) experience.
A considerable proportion of tumors with
anaplasia have occurred in the setting of prior radiation therapy (38,39) even though anaplastic transformation is not always associated with a history of prior irradiation (37,38,40).
(A) Proliferacao de celulas epiteliais com discreta
anaplasia. (B) Proliferacao de celulas epiteliais distribuidas em pequenas formacoes tubulo papilares (seta) e, no permeio, verificam-se areas de diferenciacao condroide (seta cheia).
Medawar, "
Anaplasia rediviva," Annals of Internal Medicine, vol.
Only a few years ago, the golden standard for glioma classification has based mainly on their morphological features, including cells of origin, degree of differentiation, and grade of
anaplasia [21].
It is well correlated with the aggressiveness, degree of
anaplasia, invasiveness, and metastatic potential of the malignancy.
The main prognostic factors are grade and stage of tumor and cellular
anaplasia, tumor histology, the presence of vascular microinvasion, and the content of the genetic material in the cell analyzed by flow and static cytometry (DNA ploidy).
Los cortes histologicos tenidos con tincion de rutina H&E muestran una proliferacion difusa de elementos glandulares atipicos con
anaplasia celular marcada y presencia de necrosis sucia intraluminal.
Keywords:
Anaplasia, Breast, Carcinoma, Chromatin, Ductal, Fine- Needle Aspiration, Pakistan.
* Grado III: Lesiones con evidencia histologica de malignidad, mitosis,
anaplasia y capacidad infiltrativa.
Histopathologically, a high degree of cellular
anaplasia, pleomorphism, spindle to stellate shaped cells arranged in form of interlacing bundles were observed and was diagnosed as fibrosarcoma.
c-myc overexpression causes
anaplasia in medulloblastoma.
Microscopic analysis revealed that the tumour was a nephroblastoma without
anaplasia (Fig.
