levels were measured by PET using the standardized uptake value ratio (SUVR), and continued to decline in those who remained on treatment for 36 months.
Amyloid beta forms clumps called amyloid plaques
, which harm connections between nerve cells and are one of the major causes of Alzheimer's disease.
In patients treated up to 36 months, amyloid plaque
as measured by PET continued to decrease in a dose- and time-dependent manner, with amyloid plaque
levels in the 10 mg/kg fixed-dose cohort reaching and remaining at a level considered below the quantitative cut-point that discriminates between a positive and negative scan1.
If aducanumab is successful in benefitting patients with Alzheimer's disease, we may one day also become interested in understanding if aducanumab might be an option in other diseases where amyloid plaque
could play a role in the development of neurodegenerative disease - like Lewy body dementia - but clinical studies would be needed to answer that question.
"We have determined that the G protein-coupled receptor 3, a protein which also found in the brain, is responsible for the production of amyloid-beta peptides and the aggregation of amyloid plaques
," said Thorsson.
Exactly what causes the cells to die is not known, but many years before the first symptoms present themselves, pathological changes occur, such as the deposition of the protein amyloid in the form of amyloid plaques
, the accumulation of tau proteins and inflammatory changes that eventually degrade the points of contact between neurons.
"Ten years ago, amyloid plaque
detection changed much of what we do in Alzheimer's research, enabling us to identify the pathology years before any symptoms develop," Dr.
"Our study shows that both higher levels of HDL - good - and lower levels of LDL - bad - cholesterol in the bloodstream are associated with lower levels of amyloid plaque
deposits in the brain," said study leader professor Bruce Reed, from the University of California at Davis (UC Davis).
AD which is resulted from neuronal loss and atrophy particularly in temporo parietal andfrontal cortex with an inflammation response to the deposition of amyloid plaque
and abnormal cluster of protein fragments and tangled bundles of fibres (neurofibrillary Tangles-NFT) and also increased presence of monocytes or macrophages in cerebral vessel wall and reactive or reactivated microglial cell in theparenchyma (1,2) along with decrease level of neurotransmitter (NT)-Acetylcholine
The density of amyloid plaque
decreased significantly after day 14.
People who woke up more than five times each hour were more likely to have amyloid plaque
build-up compared to people who did not wake up as much.
PKC Isozymes Regulate Amyloid Plaque
and Neurofibrillary Tangle Metabolism
A clinical trial is under way at the University of California to test curcumin's effects in Alzheimer's patients and on their amyloid plaque
Their brains showed over twice as many amyloid plaque
deposits (a marker for Alzheimer's disease) as the controls.