In patients treated up to 36 months, amyloid plaque
as measured by PET continued to decrease in a dose- and time-dependent manner, with amyloid plaque
levels in the 10 mg/kg fixed-dose cohort reaching and remaining at a level considered below the quantitative cut-point that discriminates between a positive and negative scan1.
If aducanumab is successful in benefitting patients with Alzheimer's disease, we may one day also become interested in understanding if aducanumab might be an option in other diseases where amyloid plaque
could play a role in the development of neurodegenerative disease - like Lewy body dementia - but clinical studies would be needed to answer that question.
from accumulating in the brain, both of which could cause the degeneration of the central nervous system and lead to dementia as a result.
The accumulation of amyloid plaque
and the increase in number of astrocytes therefore display opposing patterns along the timeline.
Relative amounts of "good" and "bad" cholesterol in the blood influence the build-up of harmful protein deposits in the brain called beta amyloid plaques
, a study found.
The increased production of beta amyloid which may form amyloid plaques
is a main characteristic of AD.
People who woke up more than five times each hour were more likely to have amyloid plaque
build-up compared to people who did not wake up as much.
When these brains came to autopsy, however, no relationship was found between the degree of amyloid plaque
removal and the improvement of cognitive function (i.
Professor Martins is credited, in collaboration with Australian and German scientists, with isolating beta-amyloid protein, which forms amyloid plaque
deposits in the brain, a characteristic diagnostic feature of Alzheimer's disease.
A clinical trial is under way at the University of California to test curcumin's effects in Alzheimer's patients and on their amyloid plaque
Our molecular imaging approach to AD includes multiple molecular compositions that target AD associated phenomena -- low acetylcholine and amyloid plaque
Like other aging mammals, old cats have signs of amyloid plaque
and neurofibrillary tangles in their brains similar to those in humans with Alzheimer's disease.
His work, which has previously shown that oxidative stress precedes the onset of amyloid plaques
, will elucidate the role of aluminum as a modulator of brain oxidative damage, and will examine the hypothesis that vitamin E, a dietary antioxidant, could delay the onset of amyloid plaque
deposition in the animal model.
He said amyloid plaque
was common in all Alzheimer's sufferers.
In a one-year preclinical study in transgenic Alzheimer's models, EVP-0962 reduced AB1-42 peptide levels, decreased amyloid plaque
build up, reversed behavioral deficits and reduced brain inflammation associated with Alzheimer's disease.