The MSF said that the problem has been caused by a monopoly by Gilead Sciences, a pharmaceutical firm that has failed to deliver on promises to make the drug available to people suffering from HIV.Last year, Gilead announced its 'access initiative' promising lower prices for liposomal amphotericin B
(L-AMB) in 116 developing countries, Kenya included but to date, the drug largely remains inaccessible and unavailable at an affordable price in Kenya.
Liposomal amphotericin B
can be given for a longer period and at higher doses in immunocompromised patients to prevent recurrence of kala-azar.
This class consists of a single agent, amphotericin B
. Multiple lipid-based formulations have been designed and developed to limit its toxicity.
While intrathecal amphotericin B
was previously the standard treatment, it is now reserved for the more severe or refractory cases or the first trimester of pregnancy .
Conclusion: Iatrogenic acute kidney damage is a major cause of morbidity in experimental animals exposed to such nephrotoxic drugs like amphotericin B
and cyclosporine, used either alone or in combination.
The in vitro activity of amphotericin b
, itraconazole and voriconazole was evaluated against 44 isolates of Fusarium, by the disk diffusion test according to the methods provided in CLSI M38-A (16,17).
NAC species showed more resistance to fluconazole, voriconazole, caspofungin, micafungin, and amphotericin B
as compared to C.
4 shows out of 53 isolates, Candida albicans which showed sensitivity to Voriconazole were 92%, Flucytosine were 92% Amphotericin B
were 89%, Fluconazole were 81%, Micafungin were 78%, Caspofungin were 75%.
The concentrations of the drugs in combination ranged from 0.03 to 1000, 0.00024 to 2, 0.00006 to 64 and 0.00048 to 256 [micro]g [mL.sup.-1] for simvastatin, amphotericin B
, itraconazole and fluconazole, respectively.
By convention, antifungal treatment for HIV-associated CM among non-pregnant adults is divided into three phases over a minimum period of 1 year: a 2-week induction phase, including intravenous amphotericin B
deoxycholate 1 mg/kg/d as a backbone; an 8-week consolidation phase with fluconazole 400 mg/d; and a maintenance phase with fluconazole 200 mg/d (until the [CD4.sup.+] count is >200 cells/[micro]l for 6 months on ART and the HIV-1 viral load is suppressed).
Erroneous determination of hyperphosphatemia ('pseudohyperphosphatemia') in sera of patients that have been treated with liposomal amphotericin B
Introduction: Amphotericin B
is considered as one of the most effective antifungal drugs presently used to treat systemic fungal infections; however nephrotoxicity remains the major side effect.
M2 EQUITYBITES-December 17, 2013-iCo Therapeutics receives US patent for Oral Amphotericin B
M2 PHARMA-December 17, 2013-iCo Therapeutics receives US patent for Oral Amphotericin B
The first Southern African CM guideline  published in 2008 recommended treatment with 1 mg/kg/day amphotericin B
for 2 weeks--a regimen known to drive down the cryptococcal burden rapidly in cerebrospinal fluid (CSF), with many patients having sterile CSF by day 14.