and olmesartan medoxomil were supplied by Ache (Guarulhos, Brazil).
Zhang, "Study of Action and Adverse Drug Reaction of Levamlodipine Besylate and Amlodipine Besylate
," Chinese Journal of Pharmacoepidemiology, p.
There have been several studies comparing the antihypertensive efficacy and tolerability of a fixed combination of losartan (LST) and hydrochlorothiazide (HCTZ) with those of amlodipine besylate
(AMLO) in westerners.
Koya, "Liquid chromatographic method for simultaneous estimation of atorvastatin calcium and amlodipine besylate
in pharmaceutical dosage forms," International Journal of Pharma & Bio Sciences, vol.
The company's key APIs are sildenafil citrate, amlodipine besylate
, cinnarizine, omeprazole powder, triclabendazole, and others.
At that moment, he was taking oral tacrolimus, mycophenolate mofetil, prednisone, amlodipine besylate
(Norvasc), ursodiol, Kayaxelate, folic acid, multivitamins, and oral acyclovir due to a history of herpes keratitis six months prior to the evaluation.
Court of Appeals for the Federal Circuit in March invalidated the patent on Norvasc's key ingredient, amlodipine besylate
. The ruling came in a lawsuit by Pfizer against Apotex, a closely held company.
The ASCOT-BPLA trial has specifically demonstrated that a regimen starting with amlodipine besylate
is better at reducing total cardiovascular events and procedures, fatal and non-fatal stroke, and the risk of new-onset diabetes.
Food and Drug Administration (FDA) for a fixed dose combination of two antihypertensives, the calcium channel blocker (CCB) amlodipine besylate
(currently marketed by Pfizer as Norvasc) and the angiotensin receptor blocker (ARB) olmesartan medoxomil, or Benicar.
In 2007, seven popular products--Norvasc (amlodipine besylate
), Ambien (zoldipem tartrate), Zyrtec (cetirizine), Lotrel (amlodipine/benazepril), Coreg (carvedilol), Lamisil (terbinafine), and Tequin (gatifloxicin), are due to lose patent protection, noted PCMA, which could lead to $700 million in savings that year.
Data from the trial further revealed that the product was more efficacious at decreasing hypertension than the widely used hypertension drug, amlodipine besylate
. The company plans to file its New Drug Application (NDA) for marketing approval of the product with the FDA in the second half of 2016.
Paregowda, "Titrimetric and modified spectrophotometric methods for the determination of amlodipine besylate
using bromate-bromide mixture and two dyes," Science Asia, vol.
Court of Appeals for the Federal Circuit in Washington held invalid the patent on the drug's key ingredient, amlodipine besylate
, overturning a January 2006 ruling by District Judge James M.
Patients in the combination therapy group had a mean baseline blood pressure of 152.3/95.5 mm Hg, and were treated with amlodipine besylate
at 5 mg, and with benazepril hydrochloride starting at 10 mg and titrated to 20 mg after 4 weeks.