Of the 83 children who completed the study, 63 percent of those who took amitriptyline
reported feeling better, while 5 percent reported feeling worse.
While several trials have demonstrated a beneficial effect of antidepressants, including amitriptyline
, for the treatment of irritable bowel syndrome in adults, more research is needed to determine how effective this drug is--if at all--in children.
is a tricyclic antidepressant and has side-effects - including dry mouth, low blood pressure, dizziness and sedation.
If treatment failures were observed, patients underwent dose titration or switched antidepressants (assuming a 50/50 chance for each choice) for an additional 4-6 weeks, using fluoxetine as a secondary treatment following venlafaxine and amitriptyline
as a secondary treatment following fluoxetine.
In view of the use of antidepressants, such as, sertraline, clozapine, amitriptyline
and imipramine in the management of psychiatric disorders, it is therefore imperative to decipher whether these drugs affect brain serotonin levels, activities of liver enzymes and blood chemistry of patients.
is an antidepressant that received regulatory approval in 1983.
It was estimated that she took approximately 46 mg/kg of amitriptyline
about 4 hours before admission.
Participants who received amitriptyline
experienced the most side effects, but these people had a lower dropout rate, perhaps indicating that, on balance, the benefits outweighed the unwanted effects.
A drug called amitriptyline
, taken in small doses, can help.
belongs to the class of tricyclic antidepressants (TCAs), which have been a cornerstone of antidepressive therapy for more than 4 decades.
These include the anti-epileptic drugs topiramate (Topamax) and sodium valproate (Depakote), tricyclic antidepressants such as amitriptyline
(Elavil) and nortriptyline (Pamelor), beta blockers such as propranolol (Inderal), calcium blockers such as verapamil, and the antihistamine cyproheptadine (Periactin) in children.
2002;346:257-70), including four drugs available in the United States that were considered well-accepted treatments or had proved to be effective: metoprolol, propranolol, amitriptyline
, and valproate.
Treatment of CVS can include cyproheptadine, propranolol, and amitriptyline
during symptom-flee intervals, or ondansetron or lorazepam during prodrome to abort the episodes.
One of the earliest antidepressants, amitriptyline
, has its principal effect on serotonin.
Antidepressants such as Amitriptyline
or Doxepin may help to reduce the trigger response in the larynx.