EVALUATING THE INTERACTIONS BETWEEN AMINOACYL-tRNA SYNTHETASES
AND ELONGATION FACTOR TU IN PROTEIN SYNTHESIS
About Physiocrines Physiocrines are produced from ancient genes, aminoacyl-tRNA synthetases
, which are an intercellular gene family involved in protein synthesis.
11:00 Size Identification of Aminoacyl-tRNA Synthetases
While the anti-fungal effect of the LeuRS protein inhibition by boron-containing compounds has been established by the clinical results seen for AN2690, other proteins from the same family, known as aminoacyl-tRNA synthetases
, are well-validated targets for antibiotic drug development.
Therefore, an RNA-only-based protein synthesis system would require a set of RNA molecules capable of synthesizing aminoacyl-RNAs, which are produced by the protein aminoacyl-tRNA synthetases
in extant biology.
The Merck collaboration has focused on discovering novel compounds that inhibit the function of aminoacyl-tRNA synthetases
The focus of the collaboration will be to target specific aminoacyl-tRNA synthetases
, a family of 20 enzymes essential to the process of protein translation required for survival of all organisms.