Examples include EWSR1 rearrangements in clear cell odontogenic carcinoma and BRAF V600E point mutation in ameloblastic carcinoma. (13,14) Such tests may also increase diagnostic certainty.
Margin status after surgical excision is thought to be the key prognostic feature (15,24-27) and the best evidence relates to ameloblastic carcinoma, (2,28) primary intraosseous carcinoma, (5,17) and clear cell carcinoma.
Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma. Chin J Cancer Res.
Ameloblastic carcinoma, primary type: case report, immunohistochemical analysis and literature review.
Lopez-Corella et al., "Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma
," Pathology International, vol.
Ameloblastoma-like appearance with cytological atypia is seen in both primary and metastatic ameloblastic carcinomas
. However, the classical features of ameloblastoma including reverse polarity and peripheral palisading are usually lost.
Several authors have attempted to make a distinction between these two entities because ameloblastic carcinoma is clinically more aggressive.
The term ameloblastic carcinoma (AC) has recently been introduced to describe ameloblastomas in which there was histologically malignant transformation in association with less-differentiated metastatic growth, in other words, to describe tumours that show features of ameloblastoma intermingled with those of carcinoma .
The rarest variant of ameloblastic carcinoma is the peripheral ameloblastic carcinoma that arises from the gingival or alveolar mucosal epithelium.
This technology for the first time was applied to odontogenic tumors and compared three cases of ameloblastoma with three cases of malignant tumors (i.e., one ameloblastic carcinoma
, one clear cell odontogenic tumor, and one granular cell odontogenic tumor) by Carinci et al.
Therefore, PIOSCC must be considered in the differential diagnosis of malignant tumors of odontogenic epithelium, including ameloblastic carcinoma
, clear cell odontogenic carcinoma, central mucoepidermoid carcinoma, odontogenic ghost cell carcinoma, and a malignant variant of calcifying epithelial odontogenic tumor.
Whereas the ameloblastic carcinoma has cytologic features of malignancy not only in a primary tumour but also in a recurrence or in any metastatic deposits.
Ameloblastic carcinoma is a rare malignant lesion with characteristic histological features and behaviour that dictate a more radical surgical approach than does a simple ameloblastoma.
Naagai divided the malignant tumours with features of ameloblastoma into two groups: 1) malignant ameloblastoma 2) ameloblastic carcinoma. Malignant amelobastoma is an ameloblastoma with a benign and typical histological pattern which metastasize.
A history of radiation exposure has been reported in patients who were diagnosed with ameloblastic carcinomas
. Lifelong followup is mandatory in these patients, regardless of the treatment option.