The IBM has been used to simulate a number of problems including the swimming of eels, sperm, and bacteria [6-8], ameboid deformation , platelet aggregation during blood clotting [9,10], and the deformation of red blood cells in a shear flow .
On one hand, the microglia accumulate as a result of migration and proliferation, have an ameboid appearance, and appear to actively respond to the metastatic lung cancer cells in the brain by tightly encapsulating the tumor mass.
After incubation with PMA for 72 h, the majority of U937 cells shifted to an ameboid shape and began to aggregate and adhere, indicating the differentiation from monocytes into macrophage-like cells (Figure 1B).
Ameboid microglia (see figure 4, top right) are phagocytizing cells that clear infectious agents, cellular debris, and toxic agents and are associated with extensive degeneration as is found in stroke and brain trauma.
Notwithstanding an extensive literature on the subject, the question of the histogenesis of the inflammatory process and, especially, the origin of the phagocytic mononuclear ameboid wandering cells is not settled.