The vaccines were prepared using different dry masses (1.7, 2.2, 2.7 mg/mL) and adjuvant (montanide ISA 70, aluminum hydroxide gel
, no adjuvant).
The binary ethylene immine inactivated FMD virus suspension was mixed with either of montanide-ISA-70 (OB), lanolin and aluminum hydroxide gel
(AHG) for production of homogenized vaccines.
Five tenders for the supply of (a) soft aluminum foil of 40 & 45 micron thickness & of local production, (b) laboratory requisites & glass consumables, (c) aluminum hydroxide gel
2 %, (d) laboratory chemicals & media, also antibiotics & (e) special purpose glass.
The effect of aluminum hydroxide gel
(AHG) and oil base-montanide (OB) in inducing the antibody response in rabbits was the same.
Addition of adjuvant such as oil base (Montanide ISA 70) or aluminum hydroxide gel
(AHG) in the vaccine showed additive effect on its efficacy.
The vaccine containing aluminum hydroxide gel
(AHG) induced the antibody response (36.8 GMT) that reached the peak level on 18 days post priming and declined thereafter.