They compared vaccinated sheep to sheep injected with this widely used aluminum adjuvant
. They found the adjuvant, in itself, increased expression of inflammatory cytokines, NF-K[beta] family genes, and apoptotic genes.
Wang et al., "Effect of alternative aluminum adjuvants
on the absorption and immunogenicity of HPV16 L1 VLPs in mice," Human Vaccines, vol.
Its pathophysiology has been traced to the presence of an aluminum adjuvant
used in vaccines against hepatitis A and B virus and tetanus toxoid; the adjuvant aggregates at the site of injection.
dose guidelines in vaccine formulation for preclinical evaluations.
Israeli researcher Rotem Inbar and colleagues recently conducted a laboratory study, using six-week-old female mice, to investigate behavior, autoimmune, and neurohistological responses to the human papillomavirus vaccine (HPV) Gardasil and an aluminum adjuvant
. The researchers injected groups of 19 mice with Gardasil, Gardasil plus pertussis toxin, aluminum hydroxide, or a saline solution control, "in amounts equivalent to human exposure." The pertussis toxin was added to the second group in order to produce intentional damage to the blood-brain barrier.
Each dose of [LYMErix.sup.TM] contains 30 [micro]g of lipidated recombinant outer surface protein A (OspA) of Borrelia burgdorferi sensu stricto, the causative agent of LD in North America, adsorbed onto aluminum adjuvant
Mechanisms of aluminum adjuvant
toxicity and autoimmunity in pediatric populations.
Each of the vaccines contained an aluminum adjuvant
. A June 2006 muscle biopsy revealed the presence of aluminum, confirming a diagnosis of macrophagic myofasciitis.