allogeneic

- US-based late-clinical stage allogeneic T-cell therapy company AlloVir has received Regenerative Medicine Advanced Therapy designation from the US Food and Drug Administration for Viralym-M (ALVR105), its lead allogeneic, off-the-shelf, multi-virus specific T-cell therapy, for the treatment of hemorrhagic cystitis caused by BK virus in adults and children following allogeneic hematopoietic stem cell transplantation, the company said.

"Given the challenges associated with currently available patient-sourced and adult donor cell therapies, we believe there is an important need for next-generation, allogeneic, off-the-shelf immunotherapies that are more tolerable, accessible, and affordable to patients and the healthcare system."

Celularity is a clinical-stage cell therapeutics company developing allogeneic cellular therapies harnessed from human placentas through its proprietary IMPACT platform across immuno-oncology, inflammatory and age-related diseases.

Zhong Ensheng Medical, a regenerative medicine company that promotes allogeneic mesenchymal stem cells, was established in 2009 to develop new drugs from adipose mesenchymal stem cells.

The clinical trial HERACLES is a prospective multi-centre study in four European countries to include patients that have received a first-line standard treatment of corticosteroids following allogeneic hematopoietic stem cell transplantation.

The acquisition will advance Celularity as an innovation leader through CariCord's strategic relationship with Clinimmune Labs, which operates the University of Colorado Cord Blood Bank (UCCBB), an AABB-accredited, FDA-licensed allogeneic cord blood bank supporting stem cell transplantation worldwide.

Anna Sällfors Holmqvist, M.D., Ph.D., from Lund University in Sweden, and colleagues conducted a retrospective cohort study of individuals who lived two years or more after undergoing allogeneic BMT in childhood.

Allogene is a biotechnology company with a mission to catalyze the next revolution of cell therapy through the advancement of allogeneic CAR T therapies.

On April 3, 2018, Allogene and Pfizer announced that the companies had entered into a definitive asset contribution agreement for Pfizer's allogeneic CAR T portfolio.

The symposium included updates on the National Autologous (launched in 2015) and Allogeneic (launched in 2017) Stem Cell Transplant programmes.

Professor Knuth went on to say that the symposium builds on the success of Qatar's first allogeneic Hematopoietic Stem Cell Transplantation (allogeneic HSCT), performed late last year.

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a curative treatment option for both malignant and some benign hematological diseases.

GS is a rare entity during the course of CML patients especially after allogeneic stem cell transplantation (SCT) [4-6].

In this perspective, allogeneic cells would eliminate the morbidity of harvesting procedures and the costs linked to these procedures.

The major obstacle of allogeneic transplantation is the allograft rejection due to mismatched major histocompatibility complex (MHC) antigens [1, 2].