Patients can develop GVHD, a potentially life-threatening complication, following an allogeneic
stem cell or bone marrow transplant.
The PALL (Pediatric Acute Lymphoblastic Leukemia) study is a phase 1, open label study designed to evaluate the safety and ability of UCART19 to induce molecular remission defined by MRD negativity at Day 28 to enable allogeneic
stem cell transplantation in pediatric patients with high-risk R/R B-ALL.
The patent, titled 'Osteogenic differentiation of bone marrow stem cells and mesenchymal stem cells using a combination of growth factors', will provide Bone Therapeutics with legal protection for the manufacturing methods and for the distinct cell type used in its allogeneic
cell therapy technology.
CTX101 is an allogeneic
CAR T-cell therapy currently in development by CRISPR Therapeutics for the treatment of CD 19 positive malignancies.
The incidence of GvHD in recipients of allogeneic
stem cells transplantation is increasing due to the increased number of allogeneic
transplantations survivors, older recipient age, use of alternative donor grafts and use of peripheral blood stem cells.
In an alloantigen tolerance induction model, it was shown that PD-1/PD-L1 plays an important role in maintaining long-term allogeneic
tolerance induced by infusion of ethylene carbodiimide-fixed allogeneic
The pattern of distribution of the allogeneic
cells throughout the recipient organism depends on such factors as the cell type, administration route and the immune response to transplantation (GAO et al.
For co-culture of DCs and T cells, allogeneic
The patient was considered in near complete remission; however, because of the dismal prognosis due to diffuse osteo-medullary and lymph nodes alveolar rhabdomyosarcoma, we proposed a pheno-identical allogeneic
hematopoietic peripheral-stem-cell transplantation (HSCT).
hematopoietic stem cell transplantation from HIV-naive individuals to HIV-1-positive individuals may achieve temporary antiretroviral-free remission of infection and loss of detectable HIV-1, a study shows.
Autologous blood transfusion differs from allogeneic
transfusion when the patient is transfused the blood received from other persons - blood donors.
CliniMACS Biotec, Cambridge, MA and Bergisch Gladbach, Germany, announced the US Food and Drug Administration has approved the company's CliniMACS CD34 Reagent System as a Humanitarian Use Device for the prevention of graft-versus-host disease (GvHD) in patients with acute myeloid leukemia (AMS) in first complete remission undergoing allogeneic
stem cell transplantation (SCT) from a matched related donor.
To evaluate the experience of, and services to, patients from rural and regional Australia, referred to a large urban tertiary referral hospital for allogeneic
haematopoietic cell transplantation and to compare their quality of life with similar populations.
Herein, we present a patient with PNH that received eculizumab, a humanized monoclonal antibody that blocks activation of the terminal complement at C5, before and immediately following allogeneic
peripheral stem cell transplantation.
com)-- The allogeneic
adult stem cells manufacturer, Stemedica Cell Technologies, Inc.