alloantibody

Alloantigen Tolerance Induction and Adoptive CD4+ T Cells Transfer.

Association of a B cell alloantigen with susceptibility to rheumatic fever.

As initially proposed by Billingham in 1966,14 three conditions are required for the development of GVHD: (1) the graft must contain immunologically competent cells; (2) the host itself must be incapable of mounting an effective immunologic reaction against the graft; and (3) the host must possess important transplant alloantigens that are lacking in the donor graft so that the host appears foreign to the graft.

In vivo exposure of CD4+CD25+T cells from normal naive mice to alloantigen in a T cell-deficient environment elicits spontaneous expansion of alloantigen-specific CD4+CD25+natural Treg cells, which are able to suppress allograft rejection mediated by subsequently transferred naive T cells, leading to long-term graft tolerance.

Genomic organization of the glycoprotein D gene: Duffy blood group Fya/ Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue.

Rapid determination of platelet alloantigen genotypes by polymerase chain reaction using allele-specific primers.

In the current study we have investigated the possibility of CD89 and CD206 targeting on monocytes and moDCs to enhance processing of HLA class I alloantigen and antigen presentation to CD4 T-cells, as a tool to facilitate the detection and monitoring of indirect T-cell alloreactivity.

20,21) This dimorphism is the basis of the HPA-2 platelet alloantigen system, and the allele frequencies for the threonine and methionine alleles in a typical white population are 90% and 10%, respectively.

Polychlorinated biphenyl-induced immune suppression: castration, but not adrenalectomy or RU 38486 treatment, partially restores the suppressed cytotoxic T lymphocyte response to alloantigen.

The MLC is not only a clinical method in HSCT but also an important model to show T cell activation and cytokine interaction following alloantigen recognition.