It is now considered a curable disease, thanks to researchers who demonstrated that arsenic trioxide (ATO) was effective against APL in combination with another drug called all-trans
retinoic acid (ATRA).
The technique involves genetically reprogramming blood or skin cells taken from human donors to an embryonic stem-cell-like state and then treating these immature cells with all-trans
retinoic acid to convert them into atrial-like cardiomyocytes.
* MenaQ7 PharmaPure MK-7: the only all-trans
nature-identical synthetic available that is free of cis-isomers,
Castaman et al., "Early haemorrhagic morbidity and mortality during remission induction with or without all-trans
retinoic acid in acute promyelocytic leukaemia," British Journal of Haematology, vol.
Li et al., "All-trans
retinoic acid promotes TGF-[beta]-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus," PLoS One, vol.
retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation," The Journal of Experimental Medicine, vol.
VIZIN's music video for her single featured cameos from Manila Luzon and Mariah Balenciaga from RuPaul's Drag Race, Eric Leonardos from Finding Prince Charming, and Cassandra Cass from Oxygen's Strut, a show featuring an all-trans
These new GPCRs appear to bind the same chromophores as opsins (11 -cis and all-trans
retinal) but do so using amino acids at different sites in their binding pockets.
The Phase 2a component of the study assesses the safety and pharmacodynamic effects of IMG-7289 in combination with all-trans
retinoic acid (ATRA).
In our study, hand-foot syndrome was seen in patients on Doxorubicin, Cyclophosphamide, Paclitaxel, Trastuzumab, Arsenic, All-trans
retinoic acid, Mitomycin, capecitabine.
Treatment for APL with All-trans
retinoic acid (ATRA) and hydroxyurea was started immediately along with dexamethasone for prevention of differentiation syndrome.
Tonget al., "Poor response to all-trans
retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient," Leukemia, vol.
(2008) Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans
retinoic acid and idarubicin.
Obecnie w leczeniu ostrej bialaczki promielocytowej wykorzystuje sie kwas all-trans
terinoic acid--ATRA) w polaczeniu z chemioterapia, a takze trojtlenek arsenu (arsenic trioxide - ATO) .