Those included were in-patients aged at least 18 years who had no communication problem, were using any of the agents leading to oral mucositis (alkylating agents
such as busulfan, melphalan, cyclophosphamide that are used at high doses; antimetabolites such as methotrexate, 5-fluorouracil; antibiotics such as dactinomycin, adriamycin, bleomycin, and alkaloids such as vinblastine), and who had no oral mucositis and provided informed written consent.
, specifically busulfan and melphalan, was reported to be associated with the development of FNH in preparation for bone marrow transplantation due to the formation of SOS [3 5].
We present three cases of SOS and highlight underlying risk factors for its development, such as impaired clearance of alkylating agents
in patients with renal failure and prolonged infection.
Pyrrolo-[1, 2-a] imidazoles have been synthesized by diastereoselective of 1,3dipolar cycloaddition by using 4, 5-dihydroimidazolium ylides with an alkylating agent
and base or more recently carbenoid insertion to dihydroimidazoles.
By tracking this observation, we discovered that if the original alkylating agent
was omitted from the reaction, employing instead more than a stoichiometric amount of TEBAC, a clean transfer of a unique benzyl group took place.
One of the cytotoxic mechanisms of alkylating agents
is their ability to generate free radicals and trigger oxidative stress in vivo .
Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
Premature menopause and secondary malignancies--two LEs associated with the alkylating agent
cyclophosphamide--were identified by only 71% and 62% of oncologists, respectively, along with 15% and 17%, respectively, of PCPs.
(12) This antibiotic is a potent alkylating agent
. However, there has been a reported case of laryngeal carcinoma in a nonsmoking adult that might have been related to topical mitomycin C use.
Their topics include human biotransformation, analytical tools and approaches for metabolic identification in drug metabolism, the unanticipated loss of N2 from novel DNA alkylating agent
laromustine by collision-induced dissociation, and strategies for detecting reactive intermediates in drug discovery and development.
(6) Dosages and regimens of chemotherapeutic agents have been published with different results and are usually derived from current small animal or human protocols, although most are based on an alkylating agent
paired with prednisone.
The standard treatment has traditionally consisted of intermittent pulses of an alkylating agent
and prednisone administered for 4 to 7 days every 4 to 6 weeks.
Currently, the drug is approved to treat the disease in patients that have been treated with an alkylating agent
and have failed fludarabine therapy.
-- MB is a noncorrosive alkylating agent
and does not damage food, furnishings, documents, or even sensitive electronic equipment.
TEMODAL (temozolomide) Capsule is an oral, cytotoxic alkylating agent
indicated for treating glioblastoma multiforme (GBM).