At one TRC member institution, the Massachusetts Institute of Technology (MIT), researchers are focusing their attention on the effects of simple and complex alkylating agents
, a class of DNA-damaging environmental toxins and toxicants that cause cell death, mutations, birth defects, and cancer.
Predisposition to treatment-related AML is primarily due to chemotherapy with alkylating agents
(nitrogen mustard, cyclophosphamide, procarbazine) or epipodophyllotoxins (etoposide, teniposide) (Table 3).
CHRONOS-2: A Phase III randomized, double-blind, placebo-controlled study of copanlisib in rituximab-refractory indolent NHL patients who have previously been treated with rituximab and alkylating agents
CHRONOS-3: A Phase III randomized, double-blind study evaluating the efficacy and safety of copanlisib in combination with rituximab versus rituximab monotherapy in patients with relapsed iNHL who have received at least one prior line of treatment, including rituximab and an alkylating agent
Kaplowitz and coinvestigators estimated that the incidence of secondary acute leukemias and myelodysplastic syndrome in patients with metastatic disease treated with both an alkylating agent
and a topoisomerase inhibitor was 2.
This patented methylated gene test is attractive for new brain cancer drug developers since they can more easily target their new drugs to the patients who usually do not respond to the traditional alkylating agent
cerevisiae mutants, each missing one gene, to identify genes that help cells recover from damage by the alkylating agent
methylmethane sulfonate (MMS).
DelMar's lead clinical compound, VAL-083 (dianhydrogalactitol) is a first-in-class alkylating agent
with a novel cytotoxic mechanism distinct from other alkylating agents
used in the treatment of cancer.
Nitrosamines are metabolized by mixed-function oxidase enzymes to a chemically active alkylating agent
in the rat and possibly in the human esophagus (27).
CASE STUDY: THE UNANTICIPATED LOSS OF N2 FROM NOVEL DNA ALKYLATING AGENT
LAROMUSTINE BY COLLISION-INDUCED DISSOCIATION: NOVEL REARRANGEMENTS (Ala F.
Temozolomide is an oral cytotoxic alkylating agent
This preliminary snapshot showed that expression of 325 genes was up-regulated after exposure to the alkylating agent
, while 76 genes were down-regulated.
Lomustine belongs to a class of drugs known as nitrosourea anti-tumor alkylating agent
Based on published research, the mechanism of action of VAL-083 is understood to be a bi-functional alkylating agent
; however, the functional groups associated with alkylating events has been shown to differ from other alkylating agents
used in the treatment of GBM.
Women whose cancer was treated with alkylating agent
chemotherapy or high-dose radiation to the abdomen or pelvis were most at risk of infertility.