An optimized MMC administration, which includes a period of pre-treatment dehydration, urinary alkalinization
, and a higher MMC concentration, yields lower recurrences (Grade B recommendation).
activates the intracellular pH-sensitive I(KSper), inducing the membrane potential to approach negative potentials where [Ca.
of bupivacaine for brachial plexus block.
However, the alkalinization
of the unstirred layer is already a constant factor in the nonlesioned cuticle and is immediately increased dramatically after a lesion occurs.
Improved peribulbar anaesthesia with alkalinization
This fact can be attributed to the alkalinization
of the cathodic areas which, in turn, increases the efficiency of the hydroxide/oxide passive film formed on the cathodic areas of the zinc surface.
Treatment of cystinuria aims to prevent new stone formation and consists of increased fluid intake, urine alkalinization
, and cystine-binding drugs for avoiding urinary cystine hypersaturation, which occurs when the urinary cystine concentration is >250 mg/L at pH 4.
7) Neutralization or alkalinization
of the skin has been shown to disrupt corneodesmosomes in the stratum corneum, causing functional abnormalities and aberrant permeability barrier homeostasis.
of urine may increase the excretion of uric acid via urine (1), (2).
Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization
of the urine to diminish nephrotoxicity of blood pigments.
This section also now states that "serum alkalinization
with intravenous sodium bicarbonate and hyperventilation [as needed] should be instituted in patients manifesting significant toxicity such as QRS widening," and that "dysrhythmias despite adequate alkalemia may respond to overdrive pacing, beta-agonist infusions, and magnesium therapy"
Furthermore, the reduced acid secretion leads to an alkalinization
of the small intestine, which may result in bacterial overgrowth and thus to a further decrease of the bioavailability of the vitamin.
is accompanied by salinization; in this case pH is not extremely alkaline and physical soil deterioration is less severe due to the flocculanting effect of the soluble salts.
Hence, the positive effect of alkalinization
on anaerobic energy production, which is based on the facilitated [H.
with sodium bicarbonate is the mainstay therapy for reversing rhythm disturbances (3).