The remaining five patients (20%) without primary biliary cirrhosis had alkaline phosphatase
levels more than 1.
is derived from nonskeletal sources, and osteocalcin fragments may reflect both resorption and formation.
In our laboratory, we used alkaline phosphatase
antibody in conjunction with CD45, CD11b, and CD14 to quantitate surface LAP by flow cytometry, which provides the advantage of specifically evaluating granulocytes by using forward and side scatter.
Radioprotective effect of 2-mercaptopropionylglycine 2-MPG on the alkaline phosphatase
activity in the liver of Swiss albino mice against gamma irradiation.
Bone-specific alkaline phosphatase
dropped by about 30%-35% at 1 month, but remained significant only up to 6 months.
Bovine Intestinal Alkaline Phosphatase
is being developed for sepsis treatment and has successfully passed toxicology as well as Phase I clinical studies.
Structure of the human liver/bone/kidney alkaline phosphatase
Serum total alkaline phosphatase
activity has been one of the most commonly used markers of bone formation and reflects osteoblastic activity.
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Plasma levels of two naturally occurring substrates of alkaline phosphatase
, PLP and PPI, declined following subcutaneous (SC) injection of ENB-0040.
Significant differences between males and females were not observed for any of the parameters, and only the levels of alkaline phosphatase
differed significantly among age groups.
During a 24-month treatment and followup period, levels of N-terminal telopeptide of type I collagen (NTx) and bone alkaline phosphatase
Genistein also statistically significantly decreased urinary excretion of pyridinoline and deoxypyridinoline, increased levels of bone-specific alkaline phosphatase
and insulin-like growth factor I, and did not change endometrial thickness compared with placebo.
The main end point was the proportion of patients who had a therapeutic response, which the investigators defined as either normalization of alkaline phosphatase
levels or a reduction of at least 75% in the alkaline phosphatase
excess at 6 months.