analgesic

Current analgesic and anti-hyperalgesic pharmacotherapy is insufficient to control persistent algesic states.

It is considered to be associated with knee kinetics and patellar biomechanics, (3) express algesic molecules such as the substance P, and cause pain in the anterior knee compartment.

After the algesic test, animals were sacrificed and the ipsilateral sciatic nerves, 1 cm proximal and distal to the ligation, were explanted; the portion containing the ligature was eliminated.

Adenosine is a potent algesic agent, which is released during tissue injuries (33), and as caffeine is an adenosine antagonist, it is plausible that our findings resulted from caffeine attenuating nociceptive activity induced by adenosine in the periphery.

Moreover, there is no mechanistic justification for the combination of paracetamol with another cyclo-oxygenase-2 inhibitor: The enzyme responsible for the formation of algesic prostaglandin [E.sub.2] can be blocked only once.