aldose


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Related to aldose: Aldose reductase
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  • noun

Words related to aldose

a monosaccharide sugar that contains the aldehyde group or is hemiacetal

References in periodicals archive ?
The effect of aldose reductase inhibitors on glomerular prostaglandin production and urinary albumin excretion in experimental diabetes mellitus.
The company's lead drug candidate, AT-001, is a novel aldose reductase inhibitor (ARI) that is being developed for the treatment of Diabetic Cardiomyopathy, or DbCM, a fatal fibrosis of the heart.
Ota et al., "Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats," Journal of Diabetes Research, vol.
Beyer et al., "Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)2-benzothiazolyl]methyl]-1-phthalazineacetic acid (zopolrestat) and congeners," Journal of Medicinal Chemistry, vol.
Nakamura et al., "Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture," Proceedings of the National Academy of Sciences of the United States of America, vol.
Kinoshita, "Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors," Archives of Ophthalmology, vol.
Previous investigations on this plant resulted in isolation of irregular triterpenes, perdione and perovskone, and a large amount of tanshinones with their reported biological activities including effects on cardiac function [14-16], aldose reductase inhibition [17], anti-oxidant [18,19], cytotoxic [20], binding activities with the benzodiazepine receptor [21], and apoptosis induction [22].
Salacia has also been found to inhibit aldose reductase, an enzyme normally present in the eye and in other parts of the body that facilitates the transformation of glucose into a sugar alcohol called sorbitol.
1,2,4-Oxadiazoles have been used as anti-inflammatory agent [2], pesticides and insecticides [3], benzodiazepine receptor agonist [4], histamine H-3 receptor antagonists [5] as antiviral compounds [6], aldose reductase inhibitors [7] and have been employed as a bioisostere of urea in [beta]3 adrenergic receptor agonists [8].
Higher body mass index (BMI) is associated with DR because of potential involvement of blood viscosity, altered platelet function, aldose reductase activity and vasoproliferative parameters e.g vascular endothelial growth factor6.
The major metabolic changes occurring at the cellular level are: increased aldose reductase activity (polyol-sorbitol pathway], diacylglycerol--protein kinase C activation [6] (myo-inositol pathway], the hexosamine activation pathway and formation of advanced glycation end products (AGEs].
One of the pathogenesis mechanism is aldose reductase initiated accumulation of sorbitol leading to selective degeneration of mural cells in the retinal capillaries.
Structures and aldose reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula.
Excess intracellular glucose is converted to sorbitol by aldose reductase, and sorbitol is oxidized to fructose by sorbitol dehydrogenase.