The effect of aldose
reductase inhibitors on glomerular prostaglandin production and urinary albumin excretion in experimental diabetes mellitus.
The company's lead drug candidate, AT-001, is a novel aldose
reductase inhibitor (ARI) that is being developed for the treatment of Diabetic Cardiomyopathy, or DbCM, a fatal fibrosis of the heart.
reductase: A novel therapeutic target for inflammatory pathologies.
Ota et al., "Effect of ranirestat, a new aldose
reductase inhibitor, on diabetic retinopathy in SDT rats," Journal of Diabetes Research, vol.
Beyer et al., "Novel, potent aldose
reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)2-benzothiazolyl]methyl]-1-phthalazineacetic acid (zopolrestat) and congeners," Journal of Medicinal Chemistry, vol.
Nakamura et al., "Ambient glucose and aldose
reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture," Proceedings of the National Academy of Sciences of the United States of America, vol.
Kinoshita, "Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose
reductase inhibitors," Archives of Ophthalmology, vol.
Previous investigations on this plant resulted in isolation of irregular triterpenes, perdione and perovskone, and a large amount of tanshinones with their reported biological activities including effects on cardiac function [14-16], aldose
reductase inhibition , anti-oxidant [18,19], cytotoxic , binding activities with the benzodiazepine receptor , and apoptosis induction .
Salacia has also been found to inhibit aldose
reductase, an enzyme normally present in the eye and in other parts of the body that facilitates the transformation of glucose into a sugar alcohol called sorbitol.
1,2,4-Oxadiazoles have been used as anti-inflammatory agent , pesticides and insecticides , benzodiazepine receptor agonist , histamine H-3 receptor antagonists  as antiviral compounds , aldose
reductase inhibitors  and have been employed as a bioisostere of urea in [beta]3 adrenergic receptor agonists .
Higher body mass index (BMI) is associated with DR because of potential involvement of blood viscosity, altered platelet function, aldose
reductase activity and vasoproliferative parameters e.g vascular endothelial growth factor6.
The major metabolic changes occurring at the cellular level are: increased aldose
reductase activity (polyol-sorbitol pathway], diacylglycerol--protein kinase C activation  (myo-inositol pathway], the hexosamine activation pathway and formation of advanced glycation end products (AGEs].
One of the pathogenesis mechanism is aldose
reductase initiated accumulation of sorbitol leading to selective degeneration of mural cells in the retinal capillaries.
Structures and aldose
reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula.
Excess intracellular glucose is converted to sorbitol by aldose
reductase, and sorbitol is oxidized to fructose by sorbitol dehydrogenase.