Retinal capillaries: Basement membrane thickening prevented with aldose
For example, prostaglandin G/H synthase 2 (T18) has the largest number of drug interactions while aldose
reductase (T47) has only one drug interaction.
Ischemic postconditioning during reperfusion attenuates oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose
reductase (AR) is the first and rate-limiting enzyme in polyol pathway, which catalyzes the reduction of glucose to sorbitol and then sorbitol can be converted to fructose by sorbitol dehydrogenase (SDH).
reductase activity and glucose-related opacities in incubated lenses from dogs and cats.
Chalk C, Benstead TJ, Moore F, 2007, Aldose
reductase inhibitors for the treatment of diabetic polyneuropathy.
The Xerophyta viscose aldose
reductase (ALDRXV4) confers enhanced drought and salinity tolerance to transgenic tobacco plants by scavenging methylglyoxal and reducing the membrane damage.
It is a novel extended release formulation of diepalrestat, a cocrystal of epalrestat, a reversible aldose
reductase inhibitor which blocks the breakdown of excess blood glucose into sorbitol, preventing long-term nerve and tissue damage.
reductase inhibitors from the fruits of Caesalpinia ferrea Mart.
Interestingly, human enzyme Aldose
reductase (AR), an aldo-keto reductase involved in the development of diabetic cardiovascular complications, has also been implicated in the myocardial tissue injury during ischemia/reperfusion studies, owing to the enhanced generation of ROS [90-92].
Water deprivation in the Spinifex hopping mouse leads to increased medullary aldose
reductase and compatible osmolyte mRNA expression within 3 d, indicative of increased TonEBP activity; this was concurrent with increased urine concentration.
Inhibitory effect of glucodistylin from the bark of Quercus acutissima on human recombinant aldose
reductase and sorbitol accumulation.
65 A structure of the human aldose
reductase holoenzyme implicated in diabetic complications.
In-silico molecular docking is a primary method for the discovery of ligands and has been used successfully in the discovery of many novel ligands including carbonic anhydrase II inhibitors aldose
reductase inhibitors and the retinoid receptor inhibitors .
We know that the aldose
reductase inhibitor enzyme inside the lenses of adult cats is not as abundant as it is in adult dogs.