Taken together, these findings suggest that plasma concentrations of orexins could potentially be used as an indicator for monitoring the abstinence status of patients with alcohol dependence
. Thus, if patients were able to maintain abstinence, plasma concentrations of orexin would be expected to be close to normal levels, whereas plasma concentrations of orexin would be expected to be greatly increased if patients did not maintain abstinence.
The WTP method allows valuation of the intangible costs of alcohol dependence
based on the maximum amount a person is willing to pay to reduce, eliminate, or avoid the situation.
The researchers found that participants with alcohol dependence
had volume deficits in frontal, temporal, parietal, cingulate, and insular cortices; the deficits were prominent in fontal subregions and were not dependent on sex.
Male patients of alcohol dependence
between age group 20 and 60 years.
Brain morphology at entry into treatment for alcohol dependence
is related to relapse propensity.
The sociodemographic data such as age, marital status, occupation, income, religion collected using a semi structured proforma, and clinical profile details such as age at onset of drinking, duration of drinking, age at onset of dependence, nature of alcohol, and family history of alcohol dependence
were obtained from the patients who gave their consent for participating in this study.
(7,8) Weschsler et al (4) reported that approximately 32% of college students meet the DSM-IV-TR criteria for alcohol abuse, and 6% meet the criteria for alcohol dependence
. The results of this study indicate that alcohol consumption research among college students needs to include rates of abuse and dependence, as well rates of binge drinking.
Acamprosate does not have significant drug interactions with many of the medications that are commonly used to treat alcohol dependence
and other psychiatric disorders (including naltrexone, antidepressants, anxiolytics, and hypnotics)
Biopharmaceutical company MediciNova (Nasdaq GM:MNOV) reported on Tuesday that it has completed enrollment in a clinical trial of 24 subjects in the study of MN-166 (ibudilast) in alcohol dependence
M2 PHARMA-July 1, 2015-MediciNova enrols 24 subjects under clinical trial of MN-166 (ibudilast) in alcohol dependence
Conventional genome-wide association studies (GWASs) focused on the impact of single nucleotide polymorphisms (SNPs) have identified a large number of significant or suggestive risk genes for alcohol dependence
and alcohol consumption.
Studies show men who drink excessively are two times more likely than women to meet the criteria for alcohol dependence
. Alcohol dependence
is a disease characterized by needing more and more alcohol to feel drunk and by experiencing withdrawal symptoms when attempts are made to stop drinking.
BERLIN -- Alcohol dependence
and major depressive disorder are similarly potent yet independent risk factors for suicidal behavior, according to Dr.
This book brings together experts in their prospective fields to present the most up-to-date information on a variety of different facets of the neurobiology of alcohol dependence
. By drawing on information from neurocircuitry, neuroplasticity, genes, and behavior this book is able to paint a comprehensive picture of alcohol dependence
One study indicated that "about 75% of persons who recover from alcohol dependence
do so without seeking any kind of help" (NIAAA Spectrum, 2013).