agranulocytosis


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Related to agranulocytosis: neuroleptic malignant syndrome
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Synonyms for agranulocytosis

an acute blood disorder (often caused by radiation or drug therapy) characterized by severe reduction in granulocytes

References in periodicals archive ?
Utilization pattern of metamizole in northern Sweden and risk estimates of agranulocytosis. Pharmacoepidemiol Drug Saf 2002; 11(3):239-245.
Agranulocytosis and seizure are two serious side effects of Clozapine that limit its use as the first line of treatment [7].
Agranulocytosis (including fatal cases) has been reported with other agents in the class.
(33) See for example 'A case of agranulocytosis', KT, March (1937), pp.67-68; 'An interesting case of scarlet fever (Haemorrhagic)', KT, May (1930), pp.159-60; 'Pyloric stenosis in twins', KT, July (1936), pp.143-4.
Thirty five patients were not compliant with DFO and 4 had experienced agranulocytosis with DFP therapy necessitating discontinuation.
Additionally, the halo sign is recognized as one important indicator of IPA and may mirror a band of hemorrhage surrounding a DN that developed in a patient with agranulocytosis. On the other hand, a cavity and peripheral air crescent may be caused by an exclusion of colliquative necrosis produced by neutrophilic infiltrate against the invading fungi.
Hematological side effects, including agranulocytosis, non-thrombocytopenic purpura and thrombocytopenic purpura have been associated with beta-blocking agents, in general.
Up to three per cent of patients taking clozapine may develop neutropaenia and about one per cent develop agranulocytosis.^ Risk is greatest in the first months of treatment and monitoring of white cells is required for patients every week for the first 18 weeks of therapy, then every four weeks.
However, azathioprine, (6,7) cyclophosphamide, (6) and methotrexate (12) have been used in cases of autoimmune hemolytic anemia, thrombocytopenia, and agranulocytosis associated with Sjogren's syndrome.
(3) Bone myelosuppression, pancytopenia, agranulocytosis, inflammation and necrotic changes in mucous tissues, liver cell necrosis and hepatic cirrhosis, pulmonary fibrosis, disorders of kidney function, vasculitis and skin lesions are some side effects that may occur during the use of MTX.[1] When MTX is used in high doses, calcium folinate is the recommended rescue therapy.
Necrotizing gingivitis: a possible oral manifestation of ticlopidine-induced agranulocytosis. N Z Med J 2007;120:1256.
Agranulocytosis after consumption of cocaine adulterated with levamisole (Clinical Observation).
But clozapine's use in practice has been greatly limited because of its risk of agranulocytosis (lowered white blood cell count) and the necessity for frequent blood tests to appropriately monitor this risk.
Immediate and life-threatening side effects of suramin, such as collapse and shock [2,12] have been described, as well as delayed reactions including renal failure, exfoliative dermatitis, agranulocytosis, hemolytic anemia, jaundice and severe diarrhea [2].