agonist


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Related to agonist: Agonist muscle, Dopamine agonist
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Synonyms for agonist

the principal character in a work of fiction

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someone involved in a contest or battle (as in an agon)

a muscle that contracts while another relaxes

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(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction

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References in periodicals archive ?
LIDDS' single intratumoral injections of a NanoZolid formulated STING agonist has been proven to achieve significant effects on tumour growth reduction and overall survival, the private company disclosed on Thursday.
Although GnRH agonist initially binds and activates GnRH-receptors inducing a transient rise in gonadotropins, known as a flare-up, this is followed by a state of pituitary desensitization, resulting in a decrease in GnRH receptors and diminished response to GnRH stimulation.
The drug will also be the first dual TLR7and 8 agonist administered directly into a tumor in a clinical setting.
The average age of PD patients in L-dopa and L-dopa and DA agonist subgroups was older than that of de novo subgroup or HCs ( P < 0.
Our additional analyses adjusting for injecting drug use in the past month suggest that maintenance opioid agonist therapy reduces the incidence of HCV infection in part by decreasing the frequency of injection, which will also lower the risk for acquiring HIV and other blood-borne pathogens," wrote Dr.
compared the flare-up versus the long GnRH agonist regimen, and observed higher pregnancy and lower cancellation rates with the flare-up protocol (6).
Cytotoxicity interference is less of a concern for agonist-mode assays than for antagonist-mode assays because agonists that are cytotoxic at higher concentrations generate bell-shaped (inverted-U) concentration-response curves in the 460-nm channel.
This publication represents the first account of an in vivo active pepducin agonist and demonstrates the promise for pepducin technology as a novel approach to target therapeutically important GPCRs.
WASHINGTON -- The Food and Drug Administration is conducting a safety study of several commonly used prostate cancer drugs in the aftermath of a preliminary review that suggests an increase in the risk of diabetes and certain cardiovascular diseases in men treated with gonadotropin-releasing hormone (GnRH) agonists.
Dopamine agonist treatment in Parkinson's disease is associated with 2- to 3.
This study focused on generating agonist ligand data for the alpha-2 AR which mediates the antiepileptic effects of the neurotransmitter norepinephrine in the hippocampus (2).
On the basis of preclinical evaluation in animal models of human conditions, one might expect a Delta agonist to show effect in inflammatory pain, among other pain conditions.
Patients who took cabergoline, a dopamine agonist (a drug that mimics the effects of the dopamine in the brain) used to control movement problems caused by Parkinson's, were compared to others who took the dopamine agonists pergolide and pramipexole, and to a control group who did not receive a dopamine agonist.
Under the terms of the agreement, Merck will receive worldwide exclusive rights to a number of Idera's agonist compounds targeting TLR 7, 8 and 9 for use in combination with Merck's therapeutic and prophylactic vaccines under development for oncology, infectious diseases and Alzheimer's disease.
Chochinov and colleagues at Sunnybrook and Women's College Health Sciences Centre, Toronto, culled the medical literature for studies published between 1966 and 2001 that compared ephedrine with an [alpha]-1 agonist for the treatment or prevention of hypotension due to neuraxial blockade during elective C-sections among women carrying full-term pregnancies.