afibrinogenemia

Congenital afibrinogenemia. Am J Hematol 1994; 46(4):343-7.

Key words: Spleen rupture, congenital afibrinogenemia, bleeding disorder

While intracerebral hemorrhagia may be mostly seen in FX and FXIII, afibrinogenemia, and FVII deficiency, musculoskeletal bleeding (hemarthrosis and hematoma) more frequently occurs in afibrinogenemia, and FX, FXI, and FXIII deficiency (2), (6-8).

Afibrinogenemia secundaria e acidente ofidicos crotalico (Crotalus durissus terrificus).

El veneno de Cdt se caracteriza por su neurotoxicidad periferica a nivel de la placa neuromuscular, tambien posee una enzima semejante a la trombina entre otros componentes, por lo que puede causar disturbios en la coagulacion de la sangre (16,24), incluyendo afibrinogenemia (2).

rate / based on local currency (AUD) DRUGS APPROVED/LAUNCHED Drug Indication Panvax avian influenza (Australia) DRUGS PENDING APPROVAL Drug Indication Panvax avian influenza - pediatric (EU) Hemocomplettan congenital fibrinogen deficiency DRUGS IN PHASE IIB AND BEYOND Drug Indication csl718 primary immune deficiency IV immunoglobulin secondary recurrent miscarriage Beriplex blood coagulation disorders, acute major bleeding immunoglobulin G primary immune deficiency human fxlll factor XIII deficiency concentrate human fibrinogen afibrinogenemia, concentrate hypofibrinogenemia, fibrinogen deficiency zemaira emphysema caused by API deficiency TOP SELLING DRUGS Drug Indication $ (+/- %) Immunology $885 29% Plasma-derived $531 16% coagulants Recombinant FVIII $405 15% Biotherapies (incl.

Afibrinogenemia was found in one patient (n=1), 0.2% of the total.

Patients with a history of afibrinogenemia, dysfibrinogenemia, or hypofibrinogenemia were excluded from this study.

Exclusion criteria: Patients with diabetes, platelet adhesion defects such as von Willebrand disease, Bernard-Soulier syndrome or platelet aggregation defects such as Glanzmann's thrombasthenia, afibrinogenemia; history of an infectious disease in the last 10 days and use of at least one of following drugs in the last two weeks: acetylsalicylic acid, clopidogrel, ticlopidine, beta lactam antibiotics, corticosteroids and non-steroidal anti-inflammatory drugs.