Association of polymorphism in the receptor for
advanced glycation end products (RAGE) gene with circulating RAGE levels.
Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective.
Serum levels of soluble form of receptor for
advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with Type 2 diabetes.
A meta-analysis of receptor for
advanced glycation end products gene: four well-evaluated polymorphisms with diabetes mellitus.
Stern, "Activation of receptor for
advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis," Circulation Research, vol.
The present study provided two novel insights into the effects of
advanced glycation end products on bone marrow monocytes, the precursors of the macrophages.
Elevated blood glucose levels will increase the protein glycation process, which is the reaction of formation of Amadori product, which will eventually lead to the formation of
advanced glycation end products. Compared to glucose, fructose can form glycated products at an increased rate [1].
The receptor for
advanced glycation end products (RAGE) is a multiligand receptor from the immunoglobulin superfamily of cell surface receptors [1, 2].
Research has shown that reducing the intake of processed and fried foods, which are higher in toxins called
advanced glycation end products (AGEs), can reduce inflammation and restore the body's natural defenses.
(1) It is a multistep process that is initiated with the formation of Schiff bases between carbonyl group of a sugar and amino group of proteins, followed by Amadori rearrangement and finally several modifications which led to the formation of a variety of compounds known as
advanced glycation end products (AGEs).
Advanced glycation end products (AGEs) [5] are proteins, nucleic acids, or lipids that are nonenzymatically glycated by aldose sugars such as glucose.
The receptor for
advanced glycation end products (RAGE), a transmembrane multiligand receptor of the immunoglobulin superfamily, has been implicated in many chronic diseases [19, 20], including atherosclerosis, which is also believed to be an inflammatory disorder [21].
Protein glycation is a complex series of reactions occurring in all tissues and fluids where glucose reacts with proteins giving rise to a series of
advanced glycation end products (AGE) [15].
The
advanced glycation end product receptor (AGER) has different functions in the toxicity and disposal (detoxification) of
advanced glycation end products (AGEs) [9].
Metformin is a biguanide that inhibits the formation of
advanced glycation end products and reduces hepatic gluconeogenesis so it could be suggested that different extracts of plant might have inhibitory effect on the production of advanced glycation products and hepatic gluconeogenesis [11].
