Inclusion also required demonstration of bilateral selectivity of AVS, confirmed according to ratios of metanephrine or adrenal steroids
in adrenal to peripheral venous plasma (13, 23).
CAH is a genetic disorder that results in an enzyme deficiency altering the production of adrenal steroids
1949) The chemistry and partial synthesis of adrenal steroids
Data in Table 3 illustrates the adrenal recovery pattern in a chronically ill 71-yr-old woman with abnormal urinary excretion of adrenal steroids
Arthur Schwarz, a professor at Temple University and a world leader in the field of adrenal steroids
METHODS: We developed a deterministic model that describes the biosynthetic pathways for the conversion of cholesterol to adrenal steroids
and the kinetics for enzyme inhibition by metryrapone (MET), a model EAC.
I have dedicated my career to studying the effects of adrenal steroids
and their metabolites on the immune system and host resistance.
The initial work-up must include baseline gonadotropin levels (LH and FSH), gonadal sex steroids (testosterone, estradiol, and an drostenedione), and adrenal steroids
(17 [alpha]-hydroxyprogesterone, dehydroepiandrosterone and dehydroepiandrosterone sulfate).
We believe, as the world leaders in developing these adrenal steroids
, that our discoveries will for the first time allow these compounds to be converted into pharmaceuticals.
Formation of the granule cells of the dentate gyrus, in particular, is closely linked to adrenal steroids
HRPC cells appear to be able to utilize other endogenously produced adrenal steroids
as tumor growth factors.
Increased ACTH concentration, as its name implies, stimulates hyperplasia of the adrenal gland along with increased production of adrenal steroids
proximal to the enzyme block.
1-14]C]acetate incorporation into adrenal steroids
Given the results of our ongoing research, as announced today, we are increasingly confident that our efforts to deliver on the promise of these compounds as fundamental regulators of biological processes may lead to a renaissance in the therapeutic use of adrenal steroids
Sixty years after Kendall, Hench, and Reichstein were awarded the Nobel Prize for their groundbreaking research of adrenal steroids
, cortisone and other structurally related synthetic analogs remain among the most widely prescribed medications, and steroid endocrinology remains an active area of research.