The hydrocortisone reduces the secretion of ACTH, the pituitary hormone that stimulates the adrenal cortex to produce Cortisol and adrenal androgens
, thereby reducing the secretion of DHEA, androstenedione, and other adrenal androgens
Apart from the aforementioned differences in aldosterone, hybrid steroids, and adrenal androgens
, the various groups were also characterized by differences in other steroids such as corticosterone and 11-deoxycorticosterone.
Caption: Figure 1: Graphic demonstration of adrenal androgen
levels over time.
Therefore it has been hypothesized that 11KT is a major adrenal androgen
, responsible for suppression of gonadal functions observed in poorly controlled 21OHD (10).
Daniell, "DHEAS deficiency during consumption of sustained action prescribed opioids: evidence for opioid induced inhibition of adrenal androgen
production," The Journal of Pain, vol.
Belgorosky, "Relationship between the growth hormone/ insulin-like growth factor-I axis, insulin sensitivity, and adrenal androgens
in normal prepubertal and pubertal girls," The Journal of Clinical Endocrinology and Metabolism, vol.
In addition, the zR of humans and some other mammals produces so-called adrenal androgens
such as dehydroepiandrosterone.
She also had low cortisol (and its precursors 17[alpha]-hydroxyprogesterone and 11-deoxycortisol), low adrenal androgens
(DHEA sulfate and androstenedione), high mineralocorticoids precursors (11-deoxycorticosterone and corticosterone), high ACTH, and chromosomal analysis revealed a normal male karyotype 46 XY.
Accordingly, a prospective, longitudinal, and controlled study was carried out to evaluate serum ovarian and adrenal androgens
in patients with a diagnosis of complete HM before and after uterus evacuation.
We found that DHEA-sulfate correlated with calculated BAT, perhaps reflecting that adrenal androgens
and peripheral conversion to BAT may cause an elevation of BAT itself.
During the early stages of male puberty, there is a relative increase in estrogens derived mostly from peripheral aromatization of testicular and adrenal androgens
. If gynecomastia results, it usually regresses spontaneously as testicular testosterone production increases in late puberty.
Adrenal glands produce important hormones that include estrogen, testosterone, progesterone, pregnenolone, aldosterone, DHEA, and adrenal androgens
. When secretion of adrenal androgens
or other hormones is decreased, this can cause depletion of downstream sex hormones, which in turn lowers sexual function and exacerbates menopausal transition.
As is well known, sebum production correlates with levels of dehydroepiandrosterone sulfate (DHEA-S) in preadolescent girls and boys, indicating that adrenal androgens
are a major determinant of acne during this phase.
A subset of androgens, adrenal androgens
, includes any of the 19-carbon steroids synthesized by the adrenal cortex, the outer portion of the adrenal gland (zonula reticularis--innermost region of the adrenal cortex), that function as weak steroids or steroid precursors, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione.